CTRI/2021/08/035719招募中2 期
Phase II study of hypo-fractionated accelerated radiotherapy with concurrent and maintenance temozolomide in newly diagnosed IDHwt Anaplastic Astrocytoma (NCI-R-01-HyRAA) - NCI-R-01-HyRAA
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- AIIMS
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Age 18 - 65 years
- •Ã¢â?¬Â¢ Patients of either sex will be included
- •Ã¢â?¬Â¢ Karnofsky performance score 70 and above
- •Ã¢â?¬Â¢ Biopsy proven Anaplastic Astrocytoma (WHO grade III), 1p19q non-co deleted (IDH wt, ATRX retained or lost).
- •Ã¢â?¬Â¢ Baseline investigations [LFT, RFT, complete blood count] should be within normal limits Hemoglobin >10gm/dl, Platelet >100000, TLC-4000-11000
- •Ã¢â?¬Â¢ No history of prior anti-cancer treatment with radiotherapy, chemotherapy, or surgery
- •Ã¢â?¬Â¢ The patient must sign an informed consent before entry into the study
排除标准
- •Age >65 years and <18 years
- •Ã¢â?¬Â¢ Unresectable disease
- •Ã¢â?¬Â¢ Previous history of neurosurgery or radiotherapy
- •Ã¢â?¬Â¢ Recurrent disease
- •Ã¢â?¬Â¢ Patients with significant co-morbid condition
- •Ã¢â?¬Â¢ History of previous malignancy
- •Ã¢â?¬Â¢ Karnofsky Performance score below 70
- •Ã¢â?¬Â¢ Not compliant for regular follow up
- •Ã¢â?¬Â¢ Spinal AA
研究者
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