treatment of thin endometrium by exosome

Phase 1

Recruiting

Conditions: thin endometrium.
Female infertility of uterine origin
N97.2

Registration Number: IRCT20210228050535N3

Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 8

Inclusion Criteria

20-40 years old women
BMI< ; 30 Kg/m2
Lack of optimal increase in the endometrium thickness despite of increase the dose of estradiol in the previous cycle
In the previous transfer cycles, the endometrium has not reached above 7
Patients who were echogenic,
Patients whose uterine wall was not triple three-line

Exclusion Criteria

Abnormal shape of uterus in hysterosalpingography or hysteroscopy
Blood diseases or immunology
Hormonal disorders
Chromosomal and genetic abnormalities (acquired or congenital).

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endometrial thickness changes. Timepoint: One week after injection. Method of measurement: sonography.

Secondary Outcome Measures

Name	Time	Method
Implantation rate. Timepoint: 6 week after embryo transfer. Method of measurement: The number of gestational sacs divided by the number of transferred embryos.;Chemical pregnancy rate. Timepoint: Two weeks after embryo transfer. Method of measurement: Measurement of B-HCG.;Clinical pregnancy rate. Timepoint: Five weeks after embryo transfer. Method of measurement: Sonography.;Abortion rate. Timepoint: During pregnancy. Method of measurement: Sonography.;Live birth rate. Timepoint: End of pregnancy. Method of measurement: Parturition.