The effect of tiotropium-bromide on deep inspiration-induced bronchodilation and airway responsiveness in asthma.

Completed

• Conditions: allergic bronchitis; asthma; 10006436

• Registration Number: NL-OMON30190
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

18-40 yrs
history of episodic wheezing and/or dyspnoea
FEV1 > 70% of predicted
Hyperresponsive in standard histamine challenge (PC20histamine < 8 mg/ml)
Atopic
Non smoking or ex-smoking (for at least 12 months, < 5 pack years)
No usage of inhaled corticosteroids for 4 weeks prior to and during the study

Exclusion Criteria

< 18 yrs or > 40 yrs
no history of episodic wheezing and/or dyspnea
FEV1 < 70% predicted
Not hyperresponsive in standard histamine challenge (PC20histamine > 8 mg/ml)
Not allergic
smoking or ex-smoking > 5 Pack Years
Usage of inhaled corticosteroids within 4 weeks prior to and during the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>M/P ratio at 40% fall in V'40P<br /><br>Maximal dose and response to histamine<br /><br>Change of the Resistance of the respiratory system by deep inspiration (Rrs) at<br /><br>8, 12 and 16 Hz</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>baseline FEV1, FVC and FEV1/FVC ratio<br /><br>Resistance of the respiratory system at 8, 12 and 16 Hz<br /><br>Reactance of the respiratory system at 8, 12 and 16 Hz<br /><br>PC20 histamine<br /><br>PC40 histamine</p><br>