跳至主要内容
临床试验/CTRI/2024/05/067324
CTRI/2024/05/067324招募中不适用

Role of Platelet indices and Neutrophil-Lymphocyte Ratio as biomarkers to differentiate between complicated and uncomplicated appendicitis

Kasturba Medical College Manipal1 个研究点 分布在 1 个国家目标入组 106 人开始时间: 2024年5月22日最近更新:

试验速览

阶段
不适用
状态
招募中
入组人数
106
试验地点
1
主要终点
Cut-off values for Platelet Distribution Width, Mean Platelet Volume and Neutrophil-Lymphocyte Ratio to indicate higher risk of complicated appendicitis

研究概览

简要总结

After ethics committee clearance isobtained, patients diagnosed as cases of acute appendicitis with the help of USG/CECT/MRIshall be identified. The patients undergoing upfront acute appendectomy, conservativemanagement or other interventions that fulfil the inclusion and exclusion criteria will beapproached. Participant Information Sheet will be handed over to the participant. Informedconsent will be taken. In each patient, blood sample routinely sent at admission for CompleteBlood Count will be noted and parameters like PDW, MPV and total and differential counts aswell as NLR calculated henceforth analyzed in the context of their clinical and radiologicalpicture in terms of complicated vs uncomplicated appendicitis as well as the management undergone by them. Their course in the hospital until discharge will be monitored including length ofstay as well as any in hospital complications. Proforma will be filled for each patient and data**will be collected and analyzed.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • • Diagnosed case of acute appendicitis with help of USG/ CECT/ MRI • Patient undergoing upfront acute appendectomy • Conservatively managed cases of acute appendicitis • Patient consenting to be a part of the study.

排除标准

  • Patient not willing to participate in the study 2) Patient undergoing interval appendectomy surgery.
  • Cases of other infective foci- clinically 4) Appendicular tumors with appendicitis 5) Chronic inflammatory conditions 6) Autoimmune diseases 7) Immunosuppression 8) Malignancy 9) Pregnancy.

结局指标

主要结局

Cut-off values for Platelet Distribution Width, Mean Platelet Volume and Neutrophil-Lymphocyte Ratio to indicate higher risk of complicated appendicitis

时间窗: At admission

次要结局

  • Surgical versus Conservative management
  • Length of stay
  • In hospital Complications(From date of present admission till discharge)

研究者

申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Divyanshu P Aggarwal

Kasturba Medical College and Hospital, Manipal

研究点 (1)

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