Role of Platelet indices and Neutrophil-Lymphocyte Ratio as biomarkers to differentiate between complicated and uncomplicated appendicitis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 106
- Locations
- 1
- Primary Endpoint
- Cut-off values for Platelet Distribution Width, Mean Platelet Volume and Neutrophil-Lymphocyte Ratio to indicate higher risk of complicated appendicitis
Study Overview
Brief Summary
After ethics committee clearance isobtained, patients diagnosed as cases of acute appendicitis with the help of USG/CECT/MRIshall be identified. The patients undergoing upfront acute appendectomy, conservativemanagement or other interventions that fulfil the inclusion and exclusion criteria will beapproached. Participant Information Sheet will be handed over to the participant. Informedconsent will be taken. In each patient, blood sample routinely sent at admission for CompleteBlood Count will be noted and parameters like PDW, MPV and total and differential counts aswell as NLR calculated henceforth analyzed in the context of their clinical and radiologicalpicture in terms of complicated vs uncomplicated appendicitis as well as the management undergone by them. Their course in the hospital until discharge will be monitored including length ofstay as well as any in hospital complications. Proforma will be filled for each patient and data**will be collected and analyzed.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 80.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •â€¢ Diagnosed case of acute appendicitis with help of USG/ CECT/ MRI • Patient undergoing upfront acute appendectomy • Conservatively managed cases of acute appendicitis • Patient consenting to be a part of the study.
Exclusion Criteria
- •Patient not willing to participate in the study 2) Patient undergoing interval appendectomy surgery.
- •Cases of other infective foci- clinically 4) Appendicular tumors with appendicitis 5) Chronic inflammatory conditions 6) Autoimmune diseases 7) Immunosuppression 8) Malignancy 9) Pregnancy.
Outcomes
Primary Outcomes
Cut-off values for Platelet Distribution Width, Mean Platelet Volume and Neutrophil-Lymphocyte Ratio to indicate higher risk of complicated appendicitis
Time Frame: At admission
Secondary Outcomes
- Surgical versus Conservative management
- Length of stay
- In hospital Complications(From date of present admission till discharge)
Investigators
Divyanshu P Aggarwal
Kasturba Medical College and Hospital, Manipal