A Randomized Controlled Trial Comparing Deep Versus Moderate Neuromuscular Block - in Low Pressure Pneumoperitoneum - to Optimize the Surgical Conditions During Laparoscopic Donor Nephrectomy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Mean surgical rating score
研究概览
简要总结
Live kidney transplantation is first choice for patients with end-stage kidney disease. Therefore, the safety and well-being of kidneys donors are highly important objectives in live kidney donation. Low pressure pneumoperitoneum can decrease postoperative pain and therefore also concomitant use of opioids.
详细描述
However low pressure pneumoperitoneum can also decrease peri-operative conditions. In this trial the researchers will investigate whether peri-operative conditions during low pressure pneumoperitoneum can be optimized by the use of deep neuromuscular block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •obtained informed consent
- •age over 18 years
排除标准
- •chronic use of analgesics or psychotropic drugs
- •use of non-steroidal anti-inflammatory drugs shorter than 5 days before surgery
- •known or suspect allergy to rocuronium or sugammadex
- •significant liver or renal dysfunction
- •pregnant or breastfeeding
研究组 & 干预措施
Deep neuromsucular block
Deep neuromuscular block and low pressure pneumoperitoneum
干预措施: Deep neuromsucular block (Other)
Standard neuromuscular block
Standard neuromuscular block and low pressure pneumoperitoneum
结局指标
主要结局
Mean surgical rating score
时间窗: perioperative
次要结局
- Conversion to standard pressure pneumoperitoneum(perioperative)
- Length of pneumoperitoneum(perioperative)
- Intra-operative complications(perioperative)