Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee
- Registration Number
- NCT01874574
- Lead Sponsor
- Thammasat University
- Brief Summary
Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients.
- Detailed Description
Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients up to 6 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Clinical diagnosis of knee OA
- Knee pain for most days of the prior month
- Radiographic evidence consistent with knee OA
- Aged between 40 and 80 years old
Exclusion Criteria
- Lumbar spondylosis
- Gross deformity of the knee
- Co-existent inflammatory or crystal arthritis
- Prior knee surgery
- Injury to the knee in the preceding 6 months
- Any intra-articular injection in the preceding 3 months
- Pregnant or Lactating
- Current infection in the affected knee
- Inability to provide informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Corticosteroid (Triamcinolone acetonide) Corticosteroid Intra-articular injection of 1 mL of 40 mg Triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline injected at the knee by single shot Single shot Hylan G-F 20 (Synvisc) Hylan G-F 20 Intra-articular injection of the Single shot 6 mL of Hylan G-F 20 (Synvisc)
- Primary Outcome Measures
Name Time Method WOMAC Score 6 months Change from Baseline in WOMAC score at 6 months
- Secondary Outcome Measures
Name Time Method Visual Analogue Scale(VAS) 6 months Change from Baseline in VAS score at 6 months
Trial Locations
- Locations (1)
Thammasat University Hospital, Thammasat University
🇹ðŸ‡Prathumthani, Thailand