Evaluation of Human Ghrelin Levels in Patients with Chronic Periodontitis before and after Non-Surgical periodontal therapy : An Experimental Trial
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Effect of non surgical periodontal therapy on Ghrelin levels
研究概览
简要总结
Ghrelin down- regulates the lipopolysaccharide (LPS) induced pro-inflammatory cytokines production (including interleukin IL-6, IL-1β and tumor necrosis factor (TNF- alpha) and exhibits strong anti-inflammatory activity.In addition to anti-inflammatory activity, ghrelin also stimulates the differentiation and proliferation of osteoblastic cells and enhances bone formation. Further, serum gives information about periodontal pathogen-induced inflammation and reaction. Literature reveal genuine data about reducing levels of ghrelin in GCF is a site-specific inflammatory condition, for example periodontitis. Hence, this observational study will be done to analyze the quantity of ghrelin in the serum and GCF in patients of chronic periodontitis (CP) before and after scaling.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ï‚·The individuals between the age of 20-60 years and having at least 15 functional teeth.
- •ï‚· Chronic periodontitis patients having at least 30 sites that bleed on probing.
- •ï‚· Patients of CP should have periodontal pocket depth at least 5mm and clinical attachment level (CAL) at least 4mm.
排除标准
- •ï‚·Individuals with any type of systemic ailment.
- •ï‚· Pregnant or lactating patients.
- •ï‚·Patients who have been taking alcohol or smoking tobacco.
- •ï‚·The patients who received periodontal care within the last six months or who were prescribed antibiotics and analgesics during that time.
- •ï‚·Patients who are taking medications for long term especially those effecting gastric secretions.
结局指标
主要结局
Effect of non surgical periodontal therapy on Ghrelin levels
时间窗: 0 days 6 months
次要结局
- Literature reveal genuine data about reducing levels of ghrelin in GCF is a(site specific inflammatory condition for example periodontitis Hence this observational)
研究者
Shivani Gupta
Institute of dental sciences