A Multi-center Study on the Optimized Antithrombotic Therapy of Acute Myocardial Infarction With Left Ventricular Mural Thrombus.
Overview
- Phase
- Phase 4
- Intervention
- Combination of antiplatelet drugs and anticoagulants for at least one month
- Conditions
- Acute Myocardial Infarction
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Enrollment
- 120
- Primary Endpoint
- Left ventricular mural thrombus-1
- Last Updated
- 6 years ago
Overview
Brief Summary
A multi-center study will be done to explore the optimal regimen of antithrombotic therapy for acute myocardial infarction with left ventricular mural thrombus. The investigators will evaluate the different combinations of antiplatelet drugs and anticoagulants for at least one month, such as aspirin 100mg qd+clopidogrel 75mg qd+warfarin (INR1.8-2.2), aspirin 100mg qd+clopidogrel 75mg qd+dabigatran 110mg bid, aspirin 100mg qd+ticagrelor 60mg bid+warfarin (INR1.8-2.2), and aspirin 100mg qd+ticagrelor 60mg bid+dabigatran 110mg bid. Transthoracic two-dimensional echocardiography will be done at the 1-month, 3-month and 6-month follow-ups to evaluate the left ventricular mural thrombus and determinate whether the antithrombotic therapy regimen could be regulated to double antiplatelet or anticoagulant+clopidogrel 75mg qd/ticagrelor 60mg bid. Then the investigators will complete the 12-month follow-up to evaluate the efficacy and safety of the optimal antithrombotic therapy regimen for acute myocardial infarction with left ventricular mural thrombus.
Investigators
Eligibility Criteria
Inclusion Criteria
- •acute myocardial infarction with left ventricular mural thrombus
Exclusion Criteria
- •BARC bleedings ≥ 2
- •atrial fibrillation
- •acute stroke or other systemic circulation embolism
Arms & Interventions
aspirin100mg qd+clopidogrel75mg qd+warfarin (INR1.8-2.2)
Intervention: Combination of antiplatelet drugs and anticoagulants for at least one month
aspirin100mg qd+clopidogrel75mg qd+dabigatran110mg bid
Intervention: Combination of antiplatelet drugs and anticoagulants for at least one month
aspirin100mg qd+ticagrelor60mg bid+warfarin(INR1.8-2.2)
Intervention: Combination of antiplatelet drugs and anticoagulants for at least one month
aspirin100mg qd+ticagrelor60mg bid+dabigatran110mg bid
Intervention: Combination of antiplatelet drugs and anticoagulants for at least one month
Outcomes
Primary Outcomes
Left ventricular mural thrombus-1
Time Frame: 1-month
Number of Participants Without left ventricular mural thrombus as Assessed by echocardiograph at 1-month.
Left ventricular mural thrombus-3
Time Frame: 3-month
Number of Participants Without left ventricular mural thrombus as Assessed by echocardiograph at 3-month.
Left ventricular mural thrombus-6
Time Frame: 6-month
Number of Participants Without left ventricular mural thrombus as Assessed by echocardiograph at 6-month.
Secondary Outcomes
- Target vessel revascularization(12 months)
- Major cardio-cerebral vascular events(12 months)
- Recurrent myocardial infarction(12 months)
- Stent restenosis(12 months)
- Death(12 months)
- Stroke or other systemic circulation embolism(12 months)