The investigation about bone metabolism and sarcopenia among chronic hepatitis C patients and the impacts of DAAs combination therapy.
- Conditions
- Chronic hepatitis C
- Registration Number
- JPRN-UMIN000027717
- Lead Sponsor
- ippon Medical School Chiba Hokusoh Hospital
- Brief Summary
The prevalence of sarcopenia in the cirrhotic patients was significantly higher than that in the noncirrhotic patients. Sarcopenia was diagnosed in 27.5% of the 160 patients with vitamin D deficiency, and 4.5% of the 44 patients without vitamin D deficiency. On multivariate analysis, advanced age, low bodymass index and low serum 25(OH)D3 level were significant independent factors associated with sarcopenia. Serum 25(OH)D3 was positively correlated with grip strength and skeletal muscle mass index.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 204
Not provided
1. Patient who already takes some medicine affecting bone density 2. Patient who is nursing or pregnant 3. Patient with uncontrolled heart failure 4. Patient with uncontrolled hypertension or diabetes 5. Patient with chronic renal failure 6. Patient with decompensated liver cirrhosis 7. Patient with other liver diseases, including autoimmune hepatitis, primary biliary cirrhosis and alcoholic hepatitis 8. Patient with positive result for hepatitis B surface antigen and antibody to human immunodeficiency virus type-1 9. Patient Judged by investigators not to be appropriate for inclusion in this study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method