Triage of Patients Presenting Beyond 24 Hours With Ischemic Stroke Due to Vertebrobasilar Artery Occlusion

• Conditions: Stroke, Ischemic
• Interventions: Other: Endovascular Therapy

• Registration Number: NCT06510634
• Lead Sponsor: Tianjin Huanhu Hospital

Brief Summary

Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW). The efficacy and safety of EVT beyond the 24-hour window remain uncertain.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-01
• Primary Completion: 2024-04-01
• Study First Submitted: 2024-07-14
• Study First Submitted QC: 2024-07-14
• Study First Posted: 2024-07-19
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-28
• Study Completion: 2028-03

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 236

Inclusion Criteria

1. age≥18 years.;
2. blockage in the vertebrobasilar artery, including the vertebral artery or basilar artery, determined using computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/digital subtraction angiography (DSA);
3. VBAO occurrence more than 24 hours from LKW;
4. none to mild premorbid disability defined by modified Rankin Scale (mRS) score ≤2;
5. informed consent before enrollment in the clinical trials.

Exclusion Criteria

1. neuroimaging evidence of cerebral hemorrhage on presentation;
2. lack of follow up information on outcomes at 90 days
3. serious, advanced, or terminal illness.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
best medical treatment gruop	Endovascular Therapy	BMM consisted of IVT antiplatelet drugs, anticoagulation, or combinations of these treatment modalities according to institutional guidelines.
endovascular thrombectomy group	Endovascular Therapy	The EVT group would include Stent retriever thrombectomy; Aspiration; Balloon angioplasty and/or stenting; Intra-arterial medication; Combination

Primary Outcome Measures

Name	Time	Method
proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days	90(±14)days	A 0-6 scale running from perfect health without symptoms to death.

Secondary Outcome Measures

Name	Time	Method
Mortality within 90 days	90(±14)days	mortality of any causes.
distribution of patients with Modified ranking scale (mRS) (0-3) at 90 days	90(±14)days	A 0-6 scale running from perfect health without symptoms to death.
Incidence of symptomatic intracranial haemorrhage	90(±14)days	Symptomatic intracranial hemorrhage was characterized as any type of intracranial hemorrhage observed on follow-up imaging between 22 and 36 hours and 7 days after stroke onset, accompanied by an increase of at least 4 points on the NIHSS from baseline or the lowest value within 7 days, or resulting in mortality.

Trial Locations

Locations (1)

Tianjin Huanhu Hospital; 🇨🇳 Tianjin, Tianjin, China