Triage of Patients Presenting Beyond 24 Hours With Ischemic Stroke Due to Vertebrobasilar Artery Occlusion

• Conditions: Stroke, Ischemic

• Registration Number: NCT06510634
• Lead Sponsor: Tianjin Huanhu Hospital

Brief Summary

Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW). The efficacy and safety of EVT beyond the 24-hour window remain uncertain.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-01
• Primary Completion: 2024-04-01
• Study First Submitted: 2024-07-14
• Study First Submitted QC: 2024-07-14
• Study First Posted: 2024-07-19
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-28
• Study Completion: 2028-03

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 236

Inclusion Criteria

1. age≥18 years.;
2. blockage in the vertebrobasilar artery, including the vertebral artery or basilar artery, determined using computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/digital subtraction angiography (DSA);
3. VBAO occurrence more than 24 hours from LKW;
4. none to mild premorbid disability defined by modified Rankin Scale (mRS) score ≤2;
5. informed consent before enrollment in the clinical trials.

Exclusion Criteria

1. neuroimaging evidence of cerebral hemorrhage on presentation;
2. lack of follow up information on outcomes at 90 days
3. serious, advanced, or terminal illness.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days	90(±14)days	A 0-6 scale running from perfect health without symptoms to death.

Secondary Outcome Measures

Name	Time	Method
Mortality within 90 days	90(±14)days	mortality of any causes.
distribution of patients with Modified ranking scale (mRS) (0-3) at 90 days	90(±14)days	A 0-6 scale running from perfect health without symptoms to death.
Incidence of symptomatic intracranial haemorrhage	90(±14)days	Symptomatic intracranial hemorrhage was characterized as any type of intracranial hemorrhage observed on follow-up imaging between 22 and 36 hours and 7 days after stroke onset, accompanied by an increase of at least 4 points on the NIHSS from baseline or the lowest value within 7 days, or resulting in mortality.

Trial Locations

Locations (1)

Tianjin Huanhu Hospital; 🇨🇳 Tianjin, Tianjin, China