Effectiveness and Safety of Endovascular Treatment vs. Best Medical Treatment in Patients With Vertebrobasilar Artery Occlusion Presenting Beyond 24 Hours of Last Known Well：a Prospective, Multicenter Registry Study

Tianjin Huanhu Hospital1 site in 1 country236 target enrollmentJune 1, 2019

ConditionsStroke, Ischemic

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Stroke, Ischemic
Sponsor: Tianjin Huanhu Hospital
Enrollment: 236
Locations: 1
Primary Endpoint: proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days
Status: Enrolling By Invitation
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW). The efficacy and safety of EVT beyond the 24-hour window remain uncertain.

Registry

clinicaltrials.gov

Start Date

June 1, 2019

End Date

March 2028

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

Tianjin Huanhu Hospital

Responsible Party

Principal Investigator

Ming Wei

Chief Physician

Tianjin Huanhu Hospital

Eligibility Criteria

Inclusion Criteria

•age≥18 years.;
•blockage in the vertebrobasilar artery, including the vertebral artery or basilar artery, determined using computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/digital subtraction angiography (DSA);
•VBAO occurrence more than 24 hours from LKW;
•none to mild premorbid disability defined by modified Rankin Scale (mRS) score ≤2;
•informed consent before enrollment in the clinical trials.

Exclusion Criteria

•neuroimaging evidence of cerebral hemorrhage on presentation;
•lack of follow up information on outcomes at 90 days
•serious, advanced, or terminal illness.

Outcomes

Primary Outcomes

proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days

Time Frame: 90(±14)days

A 0-6 scale running from perfect health without symptoms to death.

Secondary Outcomes

Mortality within 90 days(90(±14)days)
distribution of patients with Modified ranking scale (mRS) (0-3) at 90 days(90(±14)days)
Incidence of symptomatic intracranial haemorrhage(90(±14)days)