NCT06510634Enrolling By Invitation不适用
Effectiveness and Safety of Endovascular Treatment vs. Best Medical Treatment in Patients With Vertebrobasilar Artery Occlusion Presenting Beyond 24 Hours of Last Known Well：a Prospective, Multicenter Registry Study
Tianjin Huanhu Hospital1 个研究点 分布在 1 个国家目标入组 236 人开始时间: 2019年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 236
- 试验地点
- 1
- 主要终点
- proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days
研究概览
简要总结
Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW). The efficacy and safety of EVT beyond the 24-hour window remain uncertain.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age≥18 years.;
- •blockage in the vertebrobasilar artery, including the vertebral artery or basilar artery, determined using computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/digital subtraction angiography (DSA);
- •VBAO occurrence more than 24 hours from LKW;
- •none to mild premorbid disability defined by modified Rankin Scale (mRS) score ≤2;
- •informed consent before enrollment in the clinical trials.
排除标准
- •neuroimaging evidence of cerebral hemorrhage on presentation;
- •lack of follow up information on outcomes at 90 days
- •serious, advanced, or terminal illness.
结局指标
主要结局
proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days
时间窗: 90(±14)days
A 0-6 scale running from perfect health without symptoms to death.
次要结局
- Mortality within 90 days(90(±14)days)
- distribution of patients with Modified ranking scale (mRS) (0-3) at 90 days(90(±14)days)
- Incidence of symptomatic intracranial haemorrhage(90(±14)days)
研究者
Ming Wei
Chief Physician
Tianjin Huanhu Hospital
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Effect of Proximal Blood Flow Arrest During Endovascular ThrombectomyOcclusion, CerebrovascularStrokeNCT05020795Nottingham University Hospitals NHS Trust134
招募中
不适用
Thrombectomy Versus Best Medical Management in Large Vessel Occlusion Stroke Patients Presenting Beyond 24 Hours and With Presence of Collateral Flow on CT AngiographyStroke AcuteThrombectomyMedical TreatmentLarge Vessel OcclusionNCT06654375Tianjin Huanhu Hospital350
已完成
不适用
Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic StrokeIntracranial Artery Occlusion With Infarction (Disorder)NCT03370939Beijing Tiantan Hospital2,004
已完成
3 期
Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery OcclusionIschemic Stroke, AcuteThrombolysisEndovascular TreatmentNCT06221371Beijing Tiantan Hospital391
已完成
不适用
Selection Criteria in Endovascular Thrombectomy and Thrombolytic Therapy (SECRET) Study: Development of Patient Selection Criteria Using CT Images and Accompanying Diseases for Efficient Intravenous Thrombolytic and Intra-arterial Recanalization Therapy in Acute Ischemic StrokeIschemic StrokeNCT02964052Yonsei University1,359