Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 54
- 主要终点
- Comparison of postoperative PaO2/FiO2
研究概览
简要总结
Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients. The investigators hypothesized that RIPCcom, combined intervention of remote ischemic preconditioning and remote ischemic postconditioning, would confer beneficial influence on inflammatory response and resultant postoperative pulmonary dysfunction after CPB in patients undergoing complex valvular heart surgery who are at increased risk of postoperative pulmonary dysfunction.The aim of this study was to evaluate the lung-protective effect of combined remote ischemic pre- and post-conditioning in patients undergoing complex valvular heart surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing valvular heart surgery.
- •Age: 20~80.
排除标准
- •Emergency operation.
- •patients with peripheral vascular disease.
- •Patients with a known history or clinical evidence of chronic obstructive pulmonary disease.
- •Patients with hepatic or renal dysfunction
- •Patients with acute myocardial infarction within 1 week before surgery
结局指标
主要结局
Comparison of postoperative PaO2/FiO2
时间窗: at 10 minutes after anesthetic induction
Comparison of postoperative PaO2/FiO2 between RIPCcom group and Control group.
次要结局
未报告次要终点