Efficacy of inhaled DNase in children with an airway malacia and a lower respiratory tract infectio
Completed
- Conditions
- Tracheobronchomalacia, lower respiratory tract disease (LRTD)RespiratoryUnspecified acute lower respiratory infection
- Registration Number
- ISRCTN85366144
- Lead Sponsor
- Erasmus Medical Centre (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Children aged 2 - 18 years with tracheobronchomalacia (diagnosed bronchoscopically)
2. Symptoms of a lower respiratory tract infection
Exclusion Criteria
1. Indication for a course of antibiotics at presentation (assessed by paediatric pulmonologist)
2. Co-existing chronic pulmonary disease (eg cystic fibrosis, broncho pulmonary dysplasia or primary ciliary dyskinesia)
3. History of oesophageal atresia
4. Neuromuscular disease or psychomotor retardation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in mean daily Cough Symptom Score (CSS)
- Secondary Outcome Measures
Name Time Method 1. Need for additional antibiotics<br>2. Mean daily cough severity and coughability of sputum (VAS-score)<br>3. CSS and VAS on each treatment day<br>4. Lung function (FEV1, FVC, PEF, MEF25, RINT)<br>5. Parents' perception about treatment efficacy<br>6. Doctor?s diagnosed end of infection after 1 and 2 weeks treatment