Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Vascular Function

Not Applicable

• Conditions: Healthy
• Interventions: Behavioral: Eccentric exercise training

• Registration Number: NCT02007304
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-11
• Status Verified: 2013-12
• Study First Submitted: 2013-12-04
• Study First Submitted QC: 2013-12-05
• Last Update Submitted: 2013-12-05
• Study First Posted: 2013-12-10
• Last Update Posted: 2013-12-10
• Primary Completion: 2014-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

-Healthy sedentary adults

Exclusion Criteria

• obesity (BMI >30 kg/m2)
• smoking within past six months
• hypertension (high blood pressure >140/90 mmHg)
• personal history of diabetes (fasting blood glucose >126 mg/dL), heart disease, or other cardiovascular problems
• orthopedic injury that may prevent him or her from completing the exercise
• the use of over-the-counter supplements or vitamins

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Herbs	Eccentric exercise training	participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training
Placebo	Eccentric exercise training	parcipants in this group will take placebo capsule containing microcrystalline cellulose

Primary Outcome Measures

Name	Time	Method
Pulse Wave Velocity	12th week of eccentric exercise training	PWV will be measured before, 6th week, 12th week of eccentric exercise training.

Secondary Outcome Measures

Name	Time	Method
Blood pressure	12th week of intervention	Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention.

Trial Locations

Locations (1)

National Taiwan University; 🇨🇳 Taipei, Taiwan