Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Preventing Arterial Stiffening Effects Induced by Acute and Chronic Eccentric Exercise
试验速览
- 阶段
- 不适用
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Pulse Wave Velocity
研究概览
简要总结
The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy sedentary adults
排除标准
- •obesity (BMI >30 kg/m2)
- •smoking within past six months
- •hypertension (high blood pressure >140/90 mmHg)
- •personal history of diabetes (fasting blood glucose >126 mg/dL), heart disease, or other cardiovascular problems
- •orthopedic injury that may prevent him or her from completing the exercise
- •the use of over-the-counter supplements or vitamins
研究组 & 干预措施
Herbs
participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training
干预措施: Eccentric exercise training (Behavioral)
Placebo
parcipants in this group will take placebo capsule containing microcrystalline cellulose
干预措施: Eccentric exercise training (Behavioral)
结局指标
主要结局
Pulse Wave Velocity
时间窗: 12th week of eccentric exercise training
PWV will be measured before, 6th week, 12th week of eccentric exercise training.
Pulse Wave Velocity
时间窗: Before eccentric exercise and training
PWV will be measured before, 6th week, 12th week of eccentric exercise training.
Pulse Wave Velocity
时间窗: 6th week of eccentric exercise traininig
PWV will be measured before, 6th week, 12th week of eccentric exercise training.
次要结局
- Blood pressure(12th week of intervention)
- Blood pressure(Before intervention)
- Blood pressure(6th week of intervention)