Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis

Phase 3

Completed

• Conditions: Mydriasis; Dilation
• Interventions: Drug: Phentolamine Ophthalmic Solution 0.75%; Other: Phentolamine Ophthalmic Solution Vehicle (Placebo)

• Registration Number: NCT04620213
• Lead Sponsor: Ocuphire Pharma, Inc.

Brief Summary

The objectives of this study are:

* To evaluate the efficacy of Nyxol to expedite the reversal of pharmacologically-induced mydriasis across multiple mydriatic agents with an emphasis on phenylephrine

* To evaluate the efficacy of Nyxol to return subjects to baseline accommodation after worsening (with cycloplegic agents tropicamide and Paremyd)

* To evaluate the safety of Nyxol

* To evaluate any additional benefits of the reversal of pharmacologically-induced mydriasis

Detailed Description

A randomized, parallel arm, double-masked, placebo-controlled Phase 3 study in at least 168 randomized subjects (160 completed), evaluating the safety and efficacy of Nyxol in subjects with pharmacologically-induced mydriasis.

Following the successful completion of screening, each subject will be stratified by eye color and then simultaneously be randomized to mydriatic agent (unmasked) and treatment (masked).

Treatment randomization will be 1:1, Nyxol or placebo (vehicle).

Stratification by iris color will be 1:1, light or dark irides.

The mydriatic agent randomization will be 3:1:1 (2.5% phenylephrine, 1% tropicamide, and Paremyd). That is, approximately 60% of the randomized subjects will receive one drop of 2.5% phenylephrine 1 hour before treatment (96 completed subjects), approximately 20% will receive one drop of 1% tropicamide 1 hour before treatment (32 completed subjects), and approximately 20% will receive Paremyd 1 hour before treatment (32 completed subjects).

At the treatment visit, subjects who have been randomized and stratified by iris color (1:1 \[light/dark\]) will receive one of three approved mydriatic agents approximately 1 hour prior to receiving study treatment. Measurements will be measured before (-1 hour /baseline) and 60 minutes after (maximum/0 minutes) the mydriatic agent instillation in each eye (i.e. right before the study treatment is administered), and at 30 minutes, 60 minutes, 90 minutes, 2 hours, 3 hours, 4 hours, and 6 hours after treatment dosing. Measurements will include pupil diameter (PD), distance and near visual acuity (VA), accommodation, and redness in each eye.

At the Follow-Up Visit, which is 1 day after Visit 1, measurements will again be recorded 24 hours after treatment dosing.

Study Timeline

• Study First Submitted: 2020-11-02
• Study First Submitted QC: 2020-11-05
• Study First Posted: 2020-11-06
• Study Start: 2020-11-18
• Primary Completion: 2020-12-23
• Study Completion: 2021-03-15
• Results First Submitted: 2023-06-23
• Results First Submitted QC: 2023-07-21
• Status Verified: 2023-08
• Results First Posted: 2023-08-14
• Last Update Submitted: 2023-08-15
• Last Update Posted: 2023-09-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 185

Inclusion Criteria

1. Males or females ≥ 12 years of age
2. Otherwise healthy and well controlled subjects

Read More

Exclusion Criteria

Ophthalmic (in either eye):

1. Clinically significant ocular disease as deemed by the Investigator that might interfere with the study
2. Unwilling or unable to discontinue use of contact lenses at screening until study completion
3. Unwilling or unable to suspend use of topical medication at screening until study completion
4. Ocular trauma, ocular surgery or non-refractive laser treatment within the 6 months prior to screening
5. Use of any topical prescription or over-the-counter (OTC) ophthalmic medications of any kind within 7 days of screening
6. Recent or current evidence of ocular infection or inflammation in either eye
7. History of diabetic retinopathy or diabetic macular edema
8. Closed or very narrow angles that in the Investigator's opinion are potentially occludable if the subject's pupil is dilated
9. History of any traumatic (surgical or nonsurgical) or non-traumatic condition affecting the pupil or iris
10. Known allergy or contraindication to any component of the mydriatic agents or the vehicle formulation
11. History of cauterization of the punctum or punctal plug (silicone or collagen) insertion or removal

Systemic:

1. Known hypersensitivity or contraindication to α- and/or β adrenoceptor antagonists.
2. Clinically significant systemic disease that might interfere with the study
3. Initiation of treatment with or any changes to the current dosage, drug or regimen of any systemic adrenergic or cholinergic drugs within 7 days prior to screening, or during the study
4. Participation in any investigational study within 30 days prior to screening
5. Females of childbearing potential who are pregnant, nursing, planning a pregnancy, or not using a medically acceptable form of birth control
6. Resting HR outside the normal range (50-110 beats per minute)
7. Hypertension with resting diastolic BP > 105 mmHg or systolic BP > 160 mmHg

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Phentolamine Ophthalmic Solution 0.75%	Phentolamine Ophthalmic Solution 0.75%	2 drops in study eye and 1 drop in non-study eye, 1 hour post pharmacologically-induced mydriasis
Phentolamine Ophthalmic Solution Vehicle	Phentolamine Ophthalmic Solution Vehicle (Placebo)	2 drops in study eye and 1 drop in non-study eye, 1 hour post pharmacologically-induced mydriasis

Primary Outcome Measures

Name	Time	Method
Percent of Subjects' Study Eyes With Pupil Diameter Returning to Baseline	90 minutes	Percentage of subjects' study eyes returning to less than or equal to 0.2 mm from baseline pupil diameter

Secondary Outcome Measures

Name	Time	Method
Percent of Subjects' Study Eyes Pupil Diameter Returning to Baseline	up to 24 hours	Percentage of subjects' study eyesreturning to less than or equal to 0.2 mm from baseline pupil diameter
Pupil Diameter (Change From Max)	up to 24 hours	Change (mm) from maximum pharmacologically-induced mydriatic pupil diameter (0 minutes)
Percent of Subjects With Unchanged Accommodation From Baseline	up to 6 hours	Percentage of subjects with unchanged accommodation from baseline (-1 hour)

Trial Locations

Locations (12)

Clinical Site 7; 🇺🇸 Pittsburg, Kansas, United States

Clinical Site 3; 🇺🇸 Shawnee Mission, Kansas, United States

Clinical Site 11; 🇺🇸 Newport Beach, California, United States

Clinical Site 10; 🇺🇸 San Diego, California, United States

Clinical Site 9; 🇺🇸 Longwood, Florida, United States

Clinical Site 6; 🇺🇸 Orlando, Florida, United States

Clinical Site 2; 🇺🇸 Roswell, Georgia, United States

Clinical Site 12; 🇺🇸 Cincinnati, Ohio, United States

Clinical Site 5; 🇺🇸 Athens, Ohio, United States

Clinical Site 1; 🇺🇸 Cleveland, Ohio, United States

Clinical Site 8; 🇺🇸 Warwick, Rhode Island, United States

Clinical Site 4; 🇺🇸 Memphis, Tennessee, United States