Effect of One-time Versus Three-times of Umbilical Cord Milking on Neonatal Hemoglobin in Late Preterm

Not Applicable

Completed

• Conditions: Umbilical Cord Milking
• Interventions: Other: three-times umbilical cord milking; Other: one-time umbilical cord milking

• Registration Number: NCT05551390
• Lead Sponsor: Queen Savang Vadhana Memorial Hospital, Thailand

Brief Summary

To compare the neonatal hemoglobin (Hb) in late preterm between one-time versus three-times of umbilical cord milking (UCM)

Detailed Description

This was a double-blind randomized controlled trial that performed between May 2021 to March 2022 at the Obstetrics and Gynecology Department of Queen Savang Vadhana Memorial Hospital. Late preterm pregnant women (34-36+6 week's gestation) that exclude placenta accrete/percreta, placenta previa, placental abruption, congenital anomaly and hydrops fetalis, were randomized in a 1:1 ratio to either one-time or three-times UCM. The primary outcome was neonatal Hb level at 48-72 hour after birth.

Study Timeline

• Study Start: 2022-05-01
• Status Verified: 2022-09
• Primary Completion: 2022-09-01
• Study Completion: 2022-09-01
• Study First Submitted: 2022-09-06
• Study First Submitted QC: 2022-09-19
• Last Update Submitted: 2022-09-19
• Study First Posted: 2022-09-22
• Last Update Posted: 2022-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 162

Inclusion Criteria

• Late preterm pregnant women (34-36+6 week's gestation)

Exclusion Criteria

• placenta accrete
• placenta percreta
• placenta previa
• placental abruption
• congenital anomaly
• hydrops fetalis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
three-time umbilical cord milking	three-times umbilical cord milking	Before UCM procedures, in the case of vaginal delivery, the maternity doctor or nurse held the newborn below the level of the introitus. In the case of a cesarean section, the surgeon carries the newborn below the level of the incision. Then maternity nurse or doctor swiped blood in length 20 centimeters of umbilical cord into the newborn, according to the number of swipes that assigned, then cutting the umbilical cord by the international standard methods. Newborns after birth were cared for and assessed according to the newborn nursing standards of QSMH in the department of pediatrics.
one-time umbilical cord milking	one-time umbilical cord milking	Before UCM procedures, in the case of vaginal delivery, the maternity doctor or nurse held the newborn below the level of the introitus. In the case of a cesarean section, the surgeon carries the newborn below the level of the incision. Then maternity nurse or doctor swiped blood in length 20 centimeters of umbilical cord into the newborn, according to the number of swipes that assigned, then cutting the umbilical cord by the international standard methods. Newborns after birth were cared for and assessed according to the newborn nursing standards of QSMH in the department of pediatrics.

Primary Outcome Measures

Name	Time	Method
The primary outcome was neonatal Hb level	48-72 hour after birth	neonatal Hb level

Trial Locations

Locations (1)

Wachira Prachakittikul; 🇹🇭 Chon Buri, Chonburi, Thailand