Effects of High-definition Transcranial Direct Current Stimulation During Slow-wave Sleep on Associative Memory
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- face-word assciative memory task score
研究概览
简要总结
To evaluate the effects of afternoon naps and high-definition transcranial direct current stimulation (HD-tDCS) over the left dorsolateral prefrontal cortex (DLPFC) in associative memory (AM)
详细描述
Healthy adults will be randomized into three groups: a sleep with active stimulation (Sleep-A) group will receive active anode HD-tDCS during slow-wave sleep (SWS) of non-rapid eye movement sleep (NREM) at afternoon nap, a sleep with sham stimulation (Sleep-S) group will receive afternoon nap with sham stimulation, and wake with active stimulation (Wake-A) group will receive active anode HD-tDCS during wakefulness. An anode stimulation electrode will be placed in F3 (10/20 system) which intend to target the left DLPFC, and four cathodes will be placed at FCz, AFz, F7, and C5 (10/20 system). The face-word AM task and other multidimensional neuropsychological tasks will be performed before and after afternoon napping.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 18-30 years
- •healthy adults
排除标准
- •with pacemakers, skull cavities or cracks；
- •intolerance of high-definition transcranial direct current stimulation (HD-tDCS) adverse reactions；
- •left-handed；
- •diagnosed with severe mental disorders, or involved in other experiments.
研究组 & 干预措施
wake with active stimulation (Wake-A)
Participants will receive active anode HD-tDCS during wakefulness. They will receive HD-tDCS stimulation for 25 minutes while awake, then spent free time in the sleep monitoring room, remaining awake throughout the napping period
干预措施: high-definition transcranial direct current stimulation (HD-tDCS) (Device)
sleep with active stimulation (Sleep-A)
Participants will receive active anode HD-tDCS during slow-wave sleep (SWS) of non-rapid eye movement sleep (NREM) at afternoon nap. An anode stimulation electrode will be placed in F3 (10/20 system) which intended to target the left DLPFC, and four cathodes will be placed at FCz, AFz, F7, and C5 (10/20 system)
干预措施: high-definition transcranial direct current stimulation (HD-tDCS) (Device)
sleep with sham stimulation (Sleep-S)
Participants will receive afternoon nap with sham stimulation. A 30-s rising current until 2 mA is reached, with a 30-s decline immediately at the beginning and end of the stimulation section
干预措施: sham high-definition transcranial direct current stimulation (HD-tDCS) (Device)
结局指标
主要结局
face-word assciative memory task score
时间窗: 1 hour after the end of the afternoon nap
In the face-cued word association test, participants viewed 20 grayscale photographs of faces on a computer screen, each shown for 3 seconds. Each photograph was paired with a distinct word, which participants read aloud when shown. Participants were instructed to memorize the word linked to each face. One minute later, participants viewed the same 20 faces in a new random order. They were then asked to recall the associated words. Each face was scored as correct or incorrect, and the total number of correct responses formed the AM score.
face-word assciative memory task score
时间窗: 1 hour after the end of the afternoon nap
In the face-cued word association test, participants viewed 20 grayscale photographs of faces on a computer screen, each shown for 3 seconds. Each photograph was paired with a distinct word, which participants read aloud when shown. Participants were instructed to memorize the word linked to each face. One minute later, participants viewed the same 20 faces in a new random order. They were then asked to recall the associated words. Each face was scored as correct or incorrect, and the total number of correct responses formed the AM score.
次要结局
- Auditory Verbal Learning Test (AVLT) score(2 hours after the end of afternoon nap)
研究者
WANG KAI
Director of medical psychological department
Anhui Medical University