NCT00825799已完成不适用
Validation of Serum Markers as a Bioassay for Unipolar Depression
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Protein biomarker MDDScore.
研究概览
简要总结
The goal of the study is to validate a biomarker assay for unipolar depression based on serum proteins involved in inflammation, metabolism, and stress response. The study will compare patients with a current major depressive episode to individuals with no history of depression. The hypothesis is that the assay can serve as a diagnostic tool that would be more objective than standard diagnostic questionnaires.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Meets DSM-IV criteria for Bipolar Disorder, Schizophrenia, Schizoaffective disorder or other major Axis I Psychiatric disorders (except for depression and phobia per above).
- •Addison's Disease, Cushing's Disease, or other known dysfunction of the HPA-cortisol axis.
- •Rheumatoid arthritis, lupus, or other condition associated with increased inflammation.
- •Regular use of non-steroidal anti-inflammatory medications, steroids, or other medications know to interact with the inflammatory process of the HPA axis.
- •A medical condition or regular use of a mediation, which I the opinion of the investigator is likely to influence the inflammatory or HPA responses.
- •Pregnancy.
- •Meets DSM-IV criteria for substance abuse or dependence in the last month.
- •Regular cigarette smoking.
- •History of fainting or other significant adverse event during blood drawing in the past.
结局指标
主要结局
Protein biomarker MDDScore.
时间窗: 0 weeks
次要结局
- Score on Hamilton Depression Rating Scale (HDRS).(0 weeks)
研究者
研究点 (1)
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