Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke

Recruiting

• Conditions: Stroke, Ischemic; Transient Ischemic Attack; Coagulation Disorder

• Registration Number: NCT05645081
• Lead Sponsor: Cwm Taf University Health Board (NHS)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-1
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

The inclusion criteria for phase 1 (initial patient recruitment) will be:<br><br> 1. Patients with or without diagnosis of TIA made by a physician working in stroke<br> medicine, sufficiently so to start post-TIA care or so that no further investigation<br> is thought necessary to confirm or refute the diagnosis.<br><br> 2. TIA confirmed patient has been prescribed antiplatelet drugs or anticoagulants.<br><br> 3. Patients must be aged > 18 years.<br><br> 4. Patients are taking an ordinary diet by mouth.<br><br>The inclusion criteria for phase 2 (patient representing with stroke) will be:<br><br> 1. Radiological evidence, on CT and/or MR imaging of the brain of cerebral infarction,<br> with or without secondary haemorrhage.<br><br> 2. The underlying mechanism of cerebral infarction is embolic from a cardiac source<br> (e.g. atrial fibrillation), atherothromboembolic (from aorta or other large vessels<br> in the neck) or in-situ thrombosis. No further investigations are thought necessary<br> to confirm or refute the diagnosis.<br><br> 3. No further investigations are thought necessary to confirm or refute the diagnosis.<br><br> 4. Patients must be aged >18 years.<br><br> 5. Patients must not be pregnant or breast feeding.<br><br> 6. Patients are taking an ordinary diet by mouth. Exclusion Criteria<br><br>The Exclusion criteria for phase 1 (initial patient recruitment) will be:<br><br> 1. Inability to give consent.<br><br> 2. Inability to feed by mouth.<br><br> 3. Short life expectancy.<br><br> 4. Pregnancy or breastfeeding.<br><br> 5. Symptoms are readily explained by medical problems not involving focal cerebral<br> ischaemia.<br><br>The Exclusion criteria for phase 2 (patient representing with stroke) will be:<br><br> 1. Patients who have not previously given consent for follow up blood sampling.<br><br> 2. Patients who are unable to feed by mouth.<br><br> 3. Patients in whom life expectancy is short.<br><br> 4. Patient is pregnant or breast feeding.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in the endothelial derived extracellular vesicle population;Change in patient Prothrombin time