Comparative Evaluation of Efficacy of Dexamethasone 4mg and Hyaluronidase 0.5mg Mucoadhesive Patch with Intralesional Injection of Dexamethasone and Hyaluronidase for Oral Submucous Fibrosis Stage II: A Randomized Controlled Trial.

This randomized controlled trial aims to compare a non invasive mucoadhesive patch containing 4 mg dexamethasone and point 5 mg hyaluronidase applied twice weekly with mouth opening exercises versus traditional intralesional injections 4 mg dexamethasone 1500 IU hyaluronidase lignocaine in 80 Stage II Oral Submucous Fibrosis patients over a 3 month period The study conducted in a Central India oral medicine department will assess improvements in interincisal mouth opening and reduction of burning sensation using vernier caliper measurements and VAS scores at monthly intervals Data will be analyzed with STATA t tests ANOVA non parametric tests as needed with significance set at p 005 Results could validate a sustained release patient friendly patch as a viable alternative to injections improving compliance and comfort in OSMF management