Identifying genetic determinants of outcome in multiple sclerosis

Not Applicable

• Conditions: Multiple sclerosis; Nervous System Diseases

• Registration Number: ISRCTN41688895
• Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-05-04
• Last Update Posted: 15 May 2023
• Study Completion: 2025-06-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

1. A locally confirmed diagnosis of multiple sclerosis
2. At least one measure of Extended Disability Severity Score (EDSS)
3. Able to give valid informed consent

Exclusion Criteria

1. Patients with Radiologically or Clinically Isolated Syndrome (RIS or CIS)
2. Comorbidities causing significant disability likely to have confounded the reliability of the EDSS
3. Inclusion in the discovery cohort of the recently completed first progression GWAS

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Disability measured using the Extended Disability Status Scale (EDSS) and age-corrected to generate the Age-Related Multiple Sclerosis Severity (ARMSS) Score. All available measures of the ARMSS will be considered in the analysis as observed at any timepoint in the disease course.

Secondary Outcome Measures

Name	Time	Method
TIme to event measures including time to EDSS 6.0 and time to confirmed disability worsening. These variables will be assessed in the sub-group of patients with EDSS measured at multiple timepoints.