Pharmacokinetic of Amoxicillin and Clavulanacid in pneumonic, interstitial lung tissue measured by in vivo microdialysis, in patients with pleural empyema treated by decortication.
Phase 1
- Conditions
- To measure the time versus concentration profile of Amoxicillin and Clavulanacid in the interstitial space of infected lung tissue as the target site of infection following intravenous administration of Amoxicillin and Clavulanacid
- Registration Number
- EUCTR2005-003107-36-AT
- Lead Sponsor
- Department of Thoracic and Hyperbaric Surgery, University Medical School Graz
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 0
Inclusion Criteria
Patients with thoracic empyema treated by decortication and stable hemodynamic conditions, after informed consent will be included. Patients with pre-existent known drug allergy will be excluded.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Allergy against study medication, Pregnancy, Coagulopathies, positive HIV-serology, positive Hepatitis-serology, Cortisol-medication, renal insufficiency.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method