What is the impact of continuous positive airway pressure (CPAP)treatment on coronary artery disease in subjects with heavy snoring and mild sleep disordered breathing?

Not Applicable

Completed

• Conditions: Sleep Apnea; Carotid Artery Atherosclerosis; Respiratory - Sleep apnoea; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12611000250932
• Lead Sponsor: Professor John Wheatley

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-03-08
• Last Update Posted: 24 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

Snoring greater than 50% of total sleep time (TST)
Apnea hypopnea index (AHI) <30 events per hour and oxygen desaturation index of < 5 events per hour
Normal fasting bloods for lipid profile and blood sugar level
Non smoker or not smoked in the past year

Exclusion Criteria

History of stroke
History of diabetes
History of clinically severe nasal or sinus disease
History of carotid artery surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stabilisation or regression of early changes of carotid atherosclerosis by measurement of carotid IMT (intermedia thickness) per ultrasound in subjects using continuous positive airpressure therapy (CPAP)[3 months 6 months 9 months and 12 months]

Secondary Outcome Measures

Name	Time	Method
Stabilisation or regression of early changes of carotid atherosclerosis by measurement of plaque type and extent, carotid diameter and peak systolic velocity. per ultrasound in subjects using continuous positive airpressure therapy (CPAP)[3 months 6 months 9 months and 12 months]