Multiplex PCR for Severe Respiratory Infections During the COVID-19 Pandemic

Completed

• Conditions: Viral Pneumonia

• Registration Number: NCT06349707
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge.

Detailed Description

The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge:

* the main goal was to perform a retrospective investigation of the molecular virological tests in a University hospital, in order to identify non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022 during the circulation of SARS-CoV-2, for public health knowledge;

* the secondary aim was to retrospectively analyze, for a small subgroup of patients from an intensive care unit, the files of patients with positive molecular virological tests for non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022, reporting the following standard-of-care data: (i) the identification of the viruses, (ii) bioclinical features, (iii) medical impact of virological results in real life.

Study Timeline

• Status Verified: 2024-04
• Study Start: 2024-04-01
• Study First Submitted: 2024-04-04
• Study First Submitted QC: 2024-04-04
• Study First Posted: 2024-04-05
• Primary Completion: 2024-05-01
• Study Completion: 2024-06-01
• Last Update Submitted: 2025-02-14
• Last Update Posted: 2025-02-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• For adult patients, or minors 'via' parents, able to give consent - 18 intensive care patients

Exclusion Criteria

• Non-inclusion in case of refusal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Occurrence of positive viral PCR assays (not COVID-19) from hospitalizations for respiratory infections.	18 months, retrospectively	Number of patients with positive virological molecular tests (multiplex respiratory panels) from the beginning of 2021 to mid-2022, with the nature of the viruses detected and the chronology of occurrence of positive tests.

Secondary Outcome Measures

Name	Time	Method
Real-life features of patients in Intensive care (from the whole population - Outcome 1) with positive viral PCR during infectious pneumonia.	18 months, retrospectively	For the group of patients in Intensive Care: * (i) number of positive molecular virological tests detecting respiratory viruses by FilmArray Pneumonia test; * (ii) associated bioclinical data; * (iii) medical impact of virological results in real life - progression of the infection and duration of thehospitalization.

Trial Locations

Locations (1)

Schvoerer; 🇫🇷 Vandoeuvre Les Nancy, France