Evaluation of different doses of intranasal dexmeditomedine in elderly patients with hypertension undergoing cataract operation.
Phase 4
Completed
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/04/041910
- Lead Sponsor
- Department of Anaesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
elderly patients having grade 2 hypertension undergoing cataract surgery under peribulbar block, age between 60 to 75 years , BMI between 17.5 and 30 kg/m2, total body weight more than 50 kg , ASA physical status less than 3.
Exclusion Criteria
includes patient refusal, low baseline HR less 40bpm, age >75 years, heart block of any degree, known valvular heart disease, known history of renal or hepatic impairment, severe left ventricular dysfunction, obesity BMI more than 30
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method patients experiencing more than 30% decrease in systolic, diastolic or mean arterial blood pressure and the number of patients experiencing bradycardia(HR less than 40bpm) for more than one minute. We will also measure the maximum change of these variables from the baseline in each patient ( the percentage change)Timepoint: every 2.5 minutes for the first 15 minutes and every 5 minutes there after for 2 hours after drug administration
- Secondary Outcome Measures
Name Time Method The secondary outcome will be the maximum sedation levels being achieved in these patients, [excessive sedation (MOAAS less than or equal to 3 ), hypoventilation with RR less than 8 per min, drop in SpO2 to less than 92% for more than a minute and the need for airway support; nausea and vomiting within 6 hours of administration of Dexmeditomedine, time taken to achieve the maximum sedation levels. The surgeon satisfaction score with the patient cooperation during surgery will be given by the operating surgeon.Timepoint: Levels of sedation, respiratory rate, oxygen saturation levels will be noted every 2.5 min after drug administration for the first 15 minutes and every 5 minutes there after for 2 hours. Surgeon satisfaction score will be noted at the end of the surgery.