Aspirin for prevention of adverse pregnancy outcome in women with elevated alfa-feto protei

Not Applicable

Conditions: Elevated level of alfa fetoprotein in second trimester screening.

Registration Number: IRCT201203018954N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 109

Inclusion Criteria

Inclusin criteria:16-20 gestational weeks pregnant women who attend Imam khomeini hospital clinic of perinatology,and have a second trimester AFP>2.5 MOM.They are divided into 2 groups with or without aspirin.
Patients are included in study who deliver in Imam khomeini hospital.

Exclusion criteria :maternal medical disease and uterus anomalies

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Preeclampcia. Timepoint: >20 weeks gestation. Method of measurement: BP>=140/90 and 300 mg protein in 24 hour urine or ++ in a urine analysis.;Intrauterine growth restriction. Timepoint: Due to clinical condition evaluate every 4 weeks. Method of measurement: Biometry with sonography and nomograms.

Secondary Outcome Measures

Name	Time	Method
ICU admission of neonate. Timepoint: NICU admission after delivery in first 28 days of birth. Method of measurement: hospital records.;Neonatal moratlity. Timepoint: Mortality of neonate in first 28 day of birth. Method of measurement: Hospital records.;Oligohydramnios. Timepoint: >20 weeks gestation. Method of measurement: Ultrasonography.;Placenta accreta. Timepoint: In pregnancy. Method of measurement: Clinical or with ultrasonography.;Hysterectomy. Timepoint: Removal of uterus after delivery. Method of measurement: Clinical.;Relationship between increased uterine artery pulsatory index and adverse pregnancy outcome. Timepoint: Ultrasonography in 16-20 weeks gestation. Method of measurement: Doppler ultrasound of uterine arteries.