Hypofractionated radiotherapy in early laryngeal cancers
Phase 2
Recruiting
- Conditions
- laryngeal cancer.Malignant neoplasm of larynx
- Registration Number
- IRCT20230128057262N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 49
Inclusion Criteria
Definitive diagnosis of squamous cell carcinoma of the larynx based on pathology report
Glottic lesions T1-2
No involvement of neck lymph nodes (N0)
18 to 75 years old
Performance level based on ECOG less than 3
Exclusion Criteria
Other malignant histologies of the larynx except squamous cell carcinoma
History of head and neck radiotherapy
Previous history of chemotherapy
Previous history of malignancy except skin BCC
History of diabetes or uncontrolled blood pressure
History of tracheostomy
With a history of laser microsurgery
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pathologic complete response. Timepoint: Post operation. Method of measurement: Pathologic examination.
- Secondary Outcome Measures
Name Time Method Side effects. Timepoint: Weekly during intervention course. Method of measurement: Radition therapy toxicity critria.