Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis

Not Applicable

Completed

• Conditions: Nasal Mucosal Disorder; Hypersensitivity Pneumonitis
• Interventions: Procedure: nasal endoscopy

• Registration Number: NCT05723796
• Lead Sponsor: Cairo University

Brief Summary

Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa.

Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-01
• Primary Completion: 2022-10-31
• Study Completion: 2022-12-15
• Study First Submitted: 2023-01-24
• Status Verified: 2023-02
• Study First Submitted QC: 2023-02-09
• Last Update Submitted: 2023-02-09
• Study First Posted: 2023-02-13
• Last Update Posted: 2023-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• all patients with clinical and radiological features of HP

Exclusion Criteria

• respiratory failure
• patients on anticoagulants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
chronic HP patients	nasal endoscopy	-

Primary Outcome Measures

Name	Time	Method
percentage of patients with HP developed nasal mucosa granuloma and lymphocytic infiltrations as detected by nasal endoscopy	6 months	nasal endoscopy and nasal mucosa biopsy was done for all patients to measure the % of patients with nasal granuloma and lymphocytic infiltrations

Trial Locations

Locations (1)

Kasr alainy school of medicine; 🇪🇬 Cairo, Egypt