Role of Inhibitor SMADs in Stage 3 Grade B Periodontitis Before and After Periodontal Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- TGF-β, Smad6, and Smad7 levels
研究概览
简要总结
Recently, it has been stated that Smads play an active role in all conditions where transforming growth factor-beta (TGF-β) is involved, including periodontal inflammation. This study aimed to examine the levels of TGF-β and inhibitor Smads in saliva and gingival crevicular fluid (GCF) in patients with Stage 3 Grade B periodontitis before and after non-surgical periodontal treatment. Twenty (20) stage 3 grade B periodontitis and 20 periodontally healthy individuals were included in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and saliva samples were obtained at baseline and one month after treatment. TGF-β, Smad6, and Smad7 were determined by ELISA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Have at least 20 natural teeth, excluding third molars.
- •Periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting >30% of the teeth, as detected on clinical and radiographical examinations.
- •Periodontally healthy control group had no sign of gingival inflammation, no PD > 3mm and no evidence of attachment or bone loss
排除标准
- •History of systemic disease.
- •Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study.
- •Periodontal treatment during last 6 months that could affect periodontal status.
- •History of radiotherapy or chemotherapy.
- •Current pregnancy, lactation or menopause.
结局指标
主要结局
TGF-β, Smad6, and Smad7 levels
时间窗: baseline
the levels of TGF-β, Smad6, and Smad7 in gingival crevicular fluid (GCF) and saliva
次要结局
- TGF-β, Smad6, and Smad7 levels(baseline and 1st month after treatment)
研究者
Figen Öngöz Dede
T.C. ORDU ÜNİVERSİTESİ
Bulent Ecevit University