Exhaled Nitric Oxide : Biomarker of Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Endogenous exhaled Nitric Oxyde (eNO)
研究概览
简要总结
The aim of the study is to see if endogenous exhaled Nitric Oxyde (eNO) concentrations measured are significantly higher in ARDS patients admitted in ICU ; compared to control subjects in good health with no lung disease or global inflammation, operated under general anesthesia (i.e. intubated and ventilated) for thyroid or parathyroid.
详细描述
The measurement of endogenous exhaled NO is monitored using a laser spectrometer machine connected to the expiratory circuit of the respirator. The measure is non-invasive and made by sampling expiratory gaz like for capnography.
In control subjects, the measurement period corresponds to the first ten minutes after induction of anesthesia (with intubation) before surgical incision.
In ARDS patients in intensive care, the measurement of eNO is made in the first twenty-four hours after intubation and ventilation of the patient with mechanical respirator.
The primary endpoint is a significantly higher eNO concentration in patients suffering from Acute Respiratory Distress Syndrome (ARDS).
Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria: PaO2/FiO2; ventilator-free days; length of stay in intensive care and all-cause hospital mortality at 30 days.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For ARDS patients :
- •Patients with ARDS (according to the Berlin criteria) admitted in intensive care unit and intubated for less than 24 hours.
- •For control patients :
- •Patients with no major disease (classified 1 or 2 in the classification of the American Society of Anaesthesiology)
- •Patients undergoing general anaesthesia for a thyroïd or parathyroïd surgery
排除标准
- •Minors under the age of 18 years old
- •Pregnant women
- •prisoners
- •patients who have withdrawn their consent.
结局指标
主要结局
Endogenous exhaled Nitric Oxyde (eNO)
时间窗: Measurement of eNO over a period of 10 minutes just after induction of anesthesia
The primary endpoint is a significantly higher eNO concentration in ARDS patients.
次要结局
- Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria(Measurement of eNO over a period of 10 minutes within the first 24 hours after intubation)