ISRCTN53054042已完成未知
Supraphysiologic hydrocortisone in severe acute pancreatitis: a multicentre, randomised, double-blind, placebo-controlled trial
Helsinki University Central Hospital (EVO) (Finland)0 个研究点目标入组 150 人开始时间: 2008年12月4日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 150
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Patients with severe acute pancreatitis
- •2. Despite adequate fluid resuscitation (pulmonary capillary wedge pressure [PCWP] greater than 12 or central venous pressure [CVP] greater than 8 mmHg) presence of shock requiring vasopressor (norepinephrine greater than 0.2 µg/kg/min) support for at least one hour
- •3. Aged 18 to 65 years, both genders
排除标准
- •1. Lack of written informed consent from patient or next of kin
- •2. Time from admission to hospital over seven days
- •3. Vasopressor support continued without interruption over 48 hours
- •4. Aged less than 18 years or greater than 65 years
- •5. Pregnancy or breastfeeding
- •6. More than two previous attacks of acute pancreatitis
- •7. Chronic pancreatitis or presence of complication after previous acute pancreatitis like pseudocyst
- •8. Hepatitis B, hepatitis C or human immunodeficiency (HIV) infection
- •9. Presence of acute infection (urinary, pulmonary, skin or soft-tissue infection)
- •10. Major abdominal, thoracic or vascular surgery within last 30 days
- •11. Severe chronic liver disease
- •12. Severe heart failure
研究者
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