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临床试验/NCT00067873
NCT00067873已完成不适用

Exercise Training in Obesity-prone Black and White Women

University of Alabama at Birmingham2 个研究点 分布在 1 个国家目标入组 231 人开始时间: 2000年12月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
231
试验地点
2
主要终点
Weight loss

研究概览

简要总结

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

详细描述

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Time of initial weight loss was defined as the time needed to reach the goal of 25 kg/m2 BMI. The women will then be evaluated one year after this time and the amount of weight gain will be determined.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
21 Years 至 41 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

研究组 & 干预措施

Diet only

Active Comparator

干预措施: Diet (Behavioral)

Diet plus aerobic exercise

Experimental

干预措施: Diet (Behavioral)

Diet plus aerobic exercise

Experimental

干预措施: Aerobic exercise (Behavioral)

Diet plus resistance exercise

Experimental

干预措施: Diet (Behavioral)

Diet plus resistance exercise

Experimental

干预措施: Resistance exercise (Behavioral)

结局指标

主要结局

Weight loss

时间窗: 6 months

Change in weight after initial weight loss

时间窗: 12 months after initial weight loss (maximum 18 months after randomization)

Time of initial weight loss determined by days to reach BMI \<= 25 (maximum 6 months)

次要结局

  • Change in resting energy expenditure(18 months post baseline)
  • Insulin sensitivity(18 months post baseline)
  • Change in visceral fat(18 months post baseline)
  • Change in cholesterol(18 months post baseline)
  • Change in triglycerides(18 months post baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Gary Hunter, PhD

Principle Investigator

University of Alabama at Birmingham

研究点 (2)

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