Exercise Training in Obesity-prone Black and White Women

Not Applicable

Completed

• Conditions: Obesity

• Registration Number: NCT00067873
• Lead Sponsor: University of Alabama at Birmingham

Brief Summary

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Detailed Description

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Time of initial weight loss was defined as the time needed to reach the goal of 25 kg/m2 BMI. The women will then be evaluated one year after this time and the amount of weight gain will be determined.

Study Timeline

• Study Start: 2000-12
• Study First Submitted: 2003-08-29
• Study First Submitted QC: 2003-08-29
• Study First Posted: 2003-09-01
• Primary Completion: 2007-12
• Study Completion: 2007-12
• Status Verified: 2017-10
• Last Update Submitted: 2017-11-16
• Last Update Posted: 2017-11-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 231

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in weight after initial weight loss	12 months after initial weight loss (maximum 18 months after randomization)	Time of initial weight loss determined by days to reach BMI \<= 25 (maximum 6 months)
Weight loss	6 months

Secondary Outcome Measures

Name	Time	Method
Insulin sensitivity	18 months post baseline
Change in visceral fat	18 months post baseline
Change in resting energy expenditure	18 months post baseline
Change in triglycerides	18 months post baseline
Change in cholesterol	18 months post baseline

Trial Locations

Locations (1)

University of Alabama at Birmingham; 🇺🇸 Birmingham, Alabama, United States