The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Follow-Up (BFU) Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Faecal calprotectin concentrations (marker of local inflammation)
研究概览
简要总结
Worldwide, colorectal cancer is the 3rd most common cancer; risk increases with age and is modified by lifestyle factors notably diet, physical activity and obesity. The BORICC Follow-Up (BFU) Study is a 12+ year follow-up of participants recruited to the Biomarkers of Risk of Colon Cancer (BORICC) Study. This longitudinal study will investigate associations between ageing and lifestyle factors and a panel of molecular biomarkers linked with colorectal cancer risk.
详细描述
The BORICC Follow-Up (BFU) Study builds on the findings from the BORICC Study where the investigators observed associations between age and nutritional factors, including selenium and folate, and biomarkers of colorectal health.
The BFU Study will investigate the relationships between ageing (12+ years) and such biomarkers longitudinally. It is anticipated that the project will produce novel data on (i) changes in biomarkers of colorectal cancer risk with age and (ii) the effects of obesity and lifestyle factors on biomarkers of colorectal cancer risk. These biomarkers include differentially expressed proteins, DNA methylation markers and inflammation markers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Took part in the BORICC Study at baseline (recruited 2005/6)
排除标准
- •Unable to travel to the hospital to attend study visit
- •Unable to provide informed written consent
结局指标
主要结局
Faecal calprotectin concentrations (marker of local inflammation)
时间窗: 12 years (on average)
Serum high-sensitivity C-Reactive Protein concentrations (marker of systemic inflammation)
时间窗: 12 years (on average)
次要结局
- HDL cholesterol in plasma(12 years (on average))
- Faecal short-chain fatty acid concentrations(12 years (on average))
- DNA methylation in rectal mucosal biopsies(% methylation)(12 years (on average))
- Colonic crypt cell dimensions(12 years (on average))
- Parathyroid hormone in plasma(12 years (on average))
- Triglycerides in plasma(12 years (on average))
- Vitamin B12 concentrations in serum(12 years (on average))
- Folate concentrations in serum(12 years (on average))
- Gut microbiota (analysed in stool samples)(12 years (on average))
- Target gene expression in rectal mucosal biopsies(12 years (on average))
- microRNA expression in rectal mucosal biopsies(12 years (on average))
- Colonic crypt cell proliferative state(12 years (on average))
- Markers of mitochondrial function and structure in rectal mucosal biopsies(12 years (on average))
- 25-hydroxy vitamin D concentrations in serum(12 years (on average))
- LDL cholesterol in plasma(12 years (on average))
- Glucose in plasma(12 years (on average))
- HbA1c in whole blood(12 years (on average))
- Total cholesterol in plasma(12 years (on average))