Clearance of Nasal Staphylococcus Aureus Colonization With Triple Antibiotic Ointment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 216
- 试验地点
- 2
- 主要终点
- Carrier Rate for Staphylococcus Aureus
研究概览
简要总结
Staphylococcus aureus, a bacteria that lives commonly in the anterior nostrils, is seen in about 30% of healthcare workers. Applying mupirocin ointment, a prescription, to the nostrils twice daily for 5 days is the current standard of care for treatment to clear this bacteria. This research study is designed to determine the rate of clearance of this bacteria in healthcare workers who are carriers when using triple antibiotic ointment instead of mupirocin ointment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing and able to give informed consent
- •Must have consented prior to registration for the study
排除标准
- •active infection
- •concurrent treatment with antibiotics, topical or systemic
- •S. aureus decolonization attempt in prior six months
- •history of HIV
- •chemotherapy or systemic immunosuppressive therapy
- •history of neomycin allergy or sensitivity
结局指标
主要结局
Carrier Rate for Staphylococcus Aureus
时间窗: Baseline
Percentage of subjects with baseline culture positive for Staphylococcus aureus (via nasal swab)
MRSA Clearance Rate
时间窗: 14 days
Percentage of subjects with methicillin-resistant S. aureus on Baseline culture who achieved clearance with treatment.
MSSA Clearance Rate
时间窗: 14 days
Percentage of subjects with methicillin-sensitive S. aureus on Baseline culture who achieved clearance with treatment.
次要结局
未报告次要终点
研究者
Dennis West
Professor in Dermatology and Pediatrics
Northwestern University