Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment

Not Applicable

Completed

• Conditions: Nasal Carriers of Staphylococcus Aureus

• Registration Number: NCT00997139
• Lead Sponsor: Northwestern University

Brief Summary

Staphylococcus aureus, a bacteria that lives commonly in the anterior nostrils, is seen in about 30% of healthcare workers. Applying mupirocin ointment, a prescription, to the nostrils twice daily for 5 days is the current standard of care for treatment to clear this bacteria. This research study is designed to determine the rate of clearance of this bacteria in healthcare workers who are carriers when using triple antibiotic ointment instead of mupirocin ointment.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2009-10-15
• Study First Submitted QC: 2009-10-16
• Study First Posted: 2009-10-19
• Primary Completion: 2010-11
• Study Completion: 2010-11
• Results First Submitted: 2012-04-10
• Results First Submitted QC: 2012-04-10
• Results First Posted: 2012-05-08
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-11
• Last Update Posted: 2015-01-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 216

Inclusion Criteria

• Willing and able to give informed consent
• Must have consented prior to registration for the study

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Exclusion Criteria

• active infection
• concurrent treatment with antibiotics, topical or systemic
• S. aureus decolonization attempt in prior six months
• history of HIV
• chemotherapy or systemic immunosuppressive therapy
• history of neomycin allergy or sensitivity

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Carrier Rate for Staphylococcus Aureus	Baseline	Percentage of subjects with baseline culture positive for Staphylococcus aureus (via nasal swab)
MRSA Clearance Rate	14 days	Percentage of subjects with methicillin-resistant S. aureus on Baseline culture who achieved clearance with treatment.
MSSA Clearance Rate	14 days	Percentage of subjects with methicillin-sensitive S. aureus on Baseline culture who achieved clearance with treatment.

Trial Locations

Locations (1)

Northwestern University; 🇺🇸 Chicago, Illinois, United States