NCT01715961
Completed
Not Applicable
Multicentric Prospective Study to Assess the Clinical and Prognostic Value of Sarcopenia in Patients Older Than 70 Years With Diffuse Large B-cell Lymphoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diffuse Large B Cell Lymphoma
- Sponsor
- Centre Henri Becquerel
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- progression free survival
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This clinical trial is a multicentric prospective study to assess the clinical and prognostic value of sarcopenia in patients older than 70 years with diffuse large B-cell lymphoma.
Detailed Description
Sarcopenia status is assessed by CT scan imaging on the overall survival at 18 months in patients older than 70 years with diffuse large B-cell lymphoma treated by R-CHOP.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients \>= 70 years
- •DLBCL, grade IIIB follicular lymphoma or histologically proven transformed low grade lymphoma
- •Whatever the IPI score and the performance status
- •Treated by Rituximab-CHOP or Rituximab-mini-CHOP
- •CT scan imaging performed one month or less before inclusion
- •Signed informed consent
Exclusion Criteria
- •No initial CT scan imaging performed more than one month before inclusion
- •Positivity for HCV, HBV and HIV
- •Anthracycline contra-indication
Outcomes
Primary Outcomes
progression free survival
Time Frame: at 18 months
Secondary Outcomes
- progression free survival(at 24 months)
- rate of over grade 2 toxicities(at the first and second courses of chemotherapy (day 21 and day 42))
- determination of both molecular subtypes GCB and ABC(at 24 months)
Study Sites (1)
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