The Establish of Trimester-specific Reference Ranges for Thyroid Tests in Pregnant Women and the Influence of Thyroid Disorders on Pregnancy and Its Outcomes.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Detection the FT3,FT4,TSH,TPOAb of the pregnant women in trimester of pregnancy.
研究概览
简要总结
A descriptive analysis involving 300 healthy pregnant women to the establish of trimester-specific reference ranges for thyroid tests in pregnant women. 700 cases were selected as the normal pregnant population to establish a self-sequential longitudinal reference range.
详细描述
A descriptive analysis involving 300 healthy pregnant women according NACB to the establish of trimester-specific reference ranges for thyroid tests in pregnant women. According to the selection criteria, 700 cases were selected as the normal pregnant population to establish a self-sequential longitudinal reference range. The aim of this study to monitor the change of thyroid function and antibody during the course of pregnancy in those who suffer from various thyroid disorders and normal control.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •The people who lived in the city more than five years, aged between 19 and 45, or the single pregnancy women who registered or checked in Peking University international hospital would be enrolled.
- •The pregnancy confirmed by the ultrasound or blood HCG test.
- •In order to build a pregnancy reference range of normal pregnant women who must meet the NACB standard.
排除标准
- •The history of thyroid disorders.
- •Oral contraceptives or any drugs affected the function of thyroid.
- •With other chronic autoimmune disease, malignant tumor, blood disease, etc
- •Twin pregnancies and multiple pregnancies
结局指标
主要结局
Detection the FT3,FT4,TSH,TPOAb of the pregnant women in trimester of pregnancy.
时间窗: up to 2 years
Detection the FT3,FT4,TSH,TPOAb of the pregnant women in trimester of pregnancy.
次要结局
- The influence of thyroid disorders its outcomes.(up to 2 years)
- The influence of thyroid disorders on pregnancy.(up to 2 years)
研究者
Xiaomei Zhang
Director
Peking University International Hospital