Safety Study of Tetrathiomolybdate in Patients With Idiopathic Pulmonary Fibrosis

Phase 1

Completed

• Conditions: Idiopathic Pulmonary Fibrosis
• Interventions: Drug: Tetrathiomolybdate

• Registration Number: NCT00189176
• Lead Sponsor: University of Michigan

Brief Summary

This study will evaluate the safety of the administration of a copper chelating agent, tetrathiomolybdate, for patients with idiopathic pulmonary fibrosis that have failed previous treatment. The primary endpoint for this study is safety with secondary endpoints including change in pulmonary function, exercise capacity, and quality of life.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-03
• Study First Submitted: 2005-09-10
• Study First Submitted QC: 2005-09-10
• Study First Posted: 2005-09-16
• Primary Completion: 2006-05
• Study Completion: 2006-05
• Status Verified: 2013-02
• Last Update Submitted: 2013-02-05
• Last Update Posted: 2013-02-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• Diagnosis of idiopathic pulmonary fibrosis

• Disease progression despite six months of treatment (steroids with/without azathioprine or cyclophosphamide) defined by at least one of the following:

  • Increased symptoms
  • Decline in forced vital capacity of at least 10%
  • Decline in diffusion capacity for carbon monoxide of at least 20%
  • Increased infiltrate on CXR or high resolution CT scan

• Taking < 15 mg prednisone for at least 30 days prior to screening

• Age 35-80, inclusive

• Able to understand a written informed consent and comply with the study protocol

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Exclusion Criteria

• Significant environmental exposure

• Diagnosis of collagen vascular disease

• Evidence of active infection

• Clinically significant cardiac disease:

  • Myocardial infarction, coronary artery bypass or angioplasty within 6mo
  • Unstable angina pectoris
  • Congestive heart failure requiring hospitalization within 6 months
  • Uncontrolled arrhythmia

• Poorly controlled or severe diabetes mellitus

• Pregnancy or lactation

• Women of childbearing potential not using a medically approved means of contraception (i.e. oral contraceptives, intrauterine devices, diaphragm, Norplant)

• Current enrollment in another experimental protocol

Physiologic Criteria:

• FEV1/FVC < 0.60

Laboratory Criteria:

• Total bilirubin > 1.5 X upper limit normal
• AST or ALT > 3X upper limit normal
• Alkaline phosphatase > 3X upper limit normal
• White blood cell count < 2,500/mm3
• Hematocrit < 30%
• Platelets < 100,000/mm3
• Prothrombin time INR > 1.5

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Tetrathiomolybdate	Tetrathiomolybdate	-

Primary Outcome Measures

Name	Time	Method
Safety	1 year

Trial Locations

Locations (1)

University of Michigan Health System; 🇺🇸 Ann Arbor, Michigan, United States