Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- blood glucose
研究概览
简要总结
Dexmedetomidine is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, alleviate pain,and improve cardiovascular stability in the operation period. Dexmedetomidine have influence on perioperative stress response and immune function,but it is not clear.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 60 to 80 years old;
- •Type 2 diabetes;
- •Not use insulin treatment;
- •Onging general anesthesia surgery;
- •Surgery time 1-3 hours
排除标准
- •ASA classification > class II;
- •Hypertension;
- •Serious central nervous system diseases (acute stroke, uncontrolled seizures, -Severe dementia);
- •Unstable angina and acute myocardial infarction;
- •Allergy to investigational drug;
- •Hepatic and renal dysfunction
研究组 & 干预措施
N1 group: Isoflurane & saline
for normal patients: inhale Isoflurane + the same volume of saline during operation
干预措施: general anesthesia induction (Drug)
N1 group: Isoflurane & saline
for normal patients: inhale Isoflurane + the same volume of saline during operation
干预措施: Isoflurane (Drug)
N1 group: Isoflurane & saline
for normal patients: inhale Isoflurane + the same volume of saline during operation
干预措施: normal saline (Drug)
N2 group: Isoflurane & Dexmedetomidine
for normal patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
干预措施: general anesthesia induction (Drug)
N2 group: Isoflurane & Dexmedetomidine
for normal patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
干预措施: Isoflurane (Drug)
N2 group: Isoflurane & Dexmedetomidine
for normal patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
干预措施: Dexmedetomidine (Drug)
D1 group: Isoflurane & saline
for diabetes patients: inhale Isoflurane + the same volume of saline during operation
干预措施: general anesthesia induction (Drug)
D1 group: Isoflurane & saline
for diabetes patients: inhale Isoflurane + the same volume of saline during operation
干预措施: Isoflurane (Drug)
D1 group: Isoflurane & saline
for diabetes patients: inhale Isoflurane + the same volume of saline during operation
干预措施: normal saline (Drug)
D2 group: Isoflurane & Dexmedetomidi
for diabetes patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
干预措施: general anesthesia induction (Drug)
D2 group: Isoflurane & Dexmedetomidi
for diabetes patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
干预措施: Isoflurane (Drug)
D2 group: Isoflurane & Dexmedetomidi
for diabetes patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
blood glucose
时间窗: from the day before surgery to 24 hours after surgery
measure blood glucose at 3 time points,the day before surgery,Intraoperative(1 hour after surgery begain),one day after surgery(24 hours after surgery); examine the concentration of blood glucose in serum.
level of blood insulin
时间窗: from the day before surgery to 24 hours after surgery
measure the level of blood insulin at 3 time points,the day before surgery,Intraoperative(1 hour after surgery begain),one day after surgery(24 hours after surgery); use ELISA to examine the concentration of blood insulin in serum.
次要结局
- vital signs(duration of perioperative period)