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Clinical Trials/NCT03612245
NCT03612245
Completed
Not Applicable

Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis

Centre Hospitalier Universitaire de Besancon0 sites403 target enrollmentMay 1, 2008

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Infective Endocarditis
Sponsor
Centre Hospitalier Universitaire de Besancon
Enrollment
403
Primary Endpoint
Oral health status
Status
Completed
Last Updated
7 years ago

Overview

Brief Summary

Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious disease (20 % of deaths during hospitalization and 40 % after 5 years). The development of an IE results from the meeting between a bacteremia and a pre-existent heart disorder, most of the time valvular, allowing the transplant of the circulating bacteria and their multiplication in the endocardium. Recommendations of prophylactic antibiotic treatment have been established since 1954 for some medical, particularly dental procedures, at the origin of bacteremia. But this policy has recently been questioned because its efficacy has not been demonstrated.

The purpose of this study is identify the situations with risk, by comparing the oral health status and the hygiene of patients having an IE with oral streptococci to those in patients having an IE with microorganisms not of oral origin.

Detailed Description

It is a case-control observational study. The IE cases are recruited in hospitals participating to the french prospective observational "EI2008" cohort. Cases are IE with oral streptococci whereas controls are IE with microorganisms not of oral origin.

Registry
clinicaltrials.gov
Start Date
May 1, 2008
End Date
July 1, 2012
Last Updated
7 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Major patient
  • Definite IE caused by oral streptococci (case) or by non-oral pathogens (control)

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Oral health status

Time Frame: During the IE event

Dental and periodontal evaluation by a dental surgeon or a stomatologist, according to a protocol of standardized examination

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