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临床试验/NCT03612245
NCT03612245已完成不适用

Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis

Centre Hospitalier Universitaire de Besancon0 个研究点目标入组 403 人开始时间: 2008年5月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
403
主要终点
Oral health status

研究概览

简要总结

Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious disease (20 % of deaths during hospitalization and 40 % after 5 years). The development of an IE results from the meeting between a bacteremia and a pre-existent heart disorder, most of the time valvular, allowing the transplant of the circulating bacteria and their multiplication in the endocardium. Recommendations of prophylactic antibiotic treatment have been established since 1954 for some medical, particularly dental procedures, at the origin of bacteremia. But this policy has recently been questioned because its efficacy has not been demonstrated.

The purpose of this study is identify the situations with risk, by comparing the oral health status and the hygiene of patients having an IE with oral streptococci to those in patients having an IE with microorganisms not of oral origin.

详细描述

It is a case-control observational study. The IE cases are recruited in hospitals participating to the french prospective observational "EI2008" cohort.

Cases are IE with oral streptococci whereas controls are IE with microorganisms not of oral origin.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Major patient
  • Definite IE caused by oral streptococci (case) or by non-oral pathogens (control)

排除标准

  • 未提供

结局指标

主要结局

Oral health status

时间窗: During the IE event

Dental and periodontal evaluation by a dental surgeon or a stomatologist, according to a protocol of standardized examination

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

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