Effect of bag and mask ventilation with volatile anaesthetics after induction with thiopentone and vecuronium before intubation on postoperative nausea and vomiting in adult patients undergoing general anaesthesia via endotracheal tube.

Not Applicable

Conditions: Health Condition 1: O- Medical and Surgical

Registration Number: CTRI/2023/04/051914

Lead Sponsor: JSSAHER

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Adult patients of American Society of Anaesthesiologists (ASA) Physical status Class I and II, who will be scheduled to undergo elective surgery under general endotracheal anaesthesia and fulfilled the inclusion criteria mentioned hereafter, at JSS Medical College and Hospital, Mysore.

Exclusion Criteria

Patients with a history of motion sickness. Patients who are already on treatment with anti-emetics, a steroid medication, or any other drug known to cause emesis currently or in the immediate past. Patients with known hypersensitivity to isoflurane or thiopentone. Pregnant or nursing mothers. Patients with severe hepatic, renal, or cardiac diseases. Obese patients with BMI >30kg/m2. Patients with an anticipated difficult airways. Vomiting within 24 hours before surgery or of any organic etiology.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the incidence of PONV during the first twenty-four hours (24 hours) after surgery. Severity of PONV, Number of rescue antiemetic medications required, Assessment of Apfel scoring, and comparison with the incidence and severity of PONV <br/ ><br>Timepoint: At immediate, 2, 4, 6, 12, 18, and 24 hours postoperative period.

Secondary Outcome Measures

Name	Time	Method
The severity of PONV, Number of rescue antiemetic medications required, Assessment of Apfel scoring, and comparison with the incidence and severity of PONV <br/ ><br>Timepoint: At immediate, 2, 4, 6, 12, 18 and 24 hours post-operative period.