Association between selum Klotho, sleep-disordered breathing and long term prognosis in heamodialysis patients
Not Applicable
- Conditions
- end stage renal disease
- Registration Number
- JPRN-UMIN000013307
- Lead Sponsor
- Division of Nephrology, Jichi Medical University
- Brief Summary
We prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309 to 449). Patients with serum soluble Klotho levels below the lower quartile (<309 pg/mL) had significantly higher cardiovascular and all-cause mortality rates. Furthermore, the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48). We conclude that there may be a threshold for the serum soluble Klotho level associated with a higher risk of mortality.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
Not provided
Exclusion Criteria
malignat disease acute pulmonary disease patients without acceptance
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mortality
- Secondary Outcome Measures
Name Time Method cardiovascular event