The Role of Dendritic Cells in Hepatitis C Infection
Not Applicable
Completed
- Conditions
- Chronic Hepatitis C Infection
- Registration Number
- NCT00723242
- Lead Sponsor
- University College, London
- Brief Summary
The role of the dendritic cells, the most potent antigen presenting cells, in the establishment of chronic hepatitis C is not established. The study aims to define whether the dendritic cells are affected by the hepatitis C virus and whether that bears an impact on the antiviral immune response they generate. The hypothesis is explored by investigating a group of patients prior to and after the initiation of standard treatment for hepatitis C with pegylated Interferon and Ribavirin.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- anti-HCV positive
- HCV RNA positive
Exclusion Criteria
- contraindications for antiviral treatment
- concurrent chronic viral infections
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Basic science research (immunology of hepatitis C)in hepatitis c patients receiving established, standard antiviral treatment (pegylated Interferon+Ribavirin)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University College Hospital
🇬🇧London, United Kingdom