NCT02386202CompletedNot Applicable
Augmented Renal Clearance in Hemorrhagic Stroke Patients Admitted to the Neurosciences Intensive Care Unit
University of North Carolina, Chapel Hill1 site in 1 country80 target enrollmentStarted: January 2015Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- To describe the onset, magnitude, and change over time of ARC in patients with hemorrhagic stroke
Study Overview
Brief Summary
To determine the incidence and predictors of augmented renal clearance (ARC) in patients with hemorrhagic stroke.
Study Design
- Study Type
- Observational
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adults ≥ 18 years
- •Patients with hemorrhagic stroke
- •Anticipated length of stay in the neuroscience intensive care unit > 48 hours
- •Informed consent provided by the patient or by the patient's designated medical proxy
Exclusion Criteria
- •Pregnancy
- •Patients with pre-existing renal dysfunction (chronic kidney disease stages 3 - 5)
- •Patients receiving renal replacement therapy
- •Patients with an admission serum creatinine > 1.4 mg/dL
- •Patients with non-aneurysmal subarachnoid hemorrhage
- •Patients with history of nephrectomy or body mass index < 18 kg/m2
Outcomes
Primary Outcomes
To describe the onset, magnitude, and change over time of ARC in patients with hemorrhagic stroke
Time Frame: Over neurosciences intensive care unit stay
Daily 8-hour urine collections will be performed to directly measure creatinine clearance up to ICU discharge
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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