Renal hemodynamic effects of aliskiren in comparison to ramipril.
Completed
- Conditions
- essential hypertension, glomerular hypertension, overweight, obesity
- Registration Number
- NL-OMON28302
- Lead Sponsor
- niversity Medical Center Groningen (UMCG)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
1. Male caucasian patients;
2. Age >18 and <70 years;
Exclusion Criteria
1. Inability to meet inclusion criteria;
2. Previously treated (within 3 months prior to start of study) with aliskiren or ramipril;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Renal hemodynamics (GFR, ERPF, FF);<br /><br>2. Blood pressure.
- Secondary Outcome Measures
Name Time Method 1. Volume status (extracellular fluid volume - ECFV);<br /><br>2. RAAS parameters (plasma renin activity, plasma renin concentration, angiotensin II, aldosteron);<br /><br>3. Urinary and serum kidney injury markers.