Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)

Completed

• Conditions: Pneumonia, Bacterial; Subarachnoid Hemorrhage

• Registration Number: NCT05094349
• Lead Sponsor: University Hospital, Brest

Brief Summary

Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI). Infection and more precisely pneumonia have been associated with poor outcome in SAH. However, the interaction between the two pathologic events remains unclear. Therefore, we hypothesized that DCI may be associated to pneumonia in SAH patients. Thus the aim of the study is to analyze the association between delayed cerebral infarction and pneumonia in patients with SAH.

Retrospective, observational, monocentric cohort study, including patient admitted in Neurosurgical Intensive Care Unit or Surgical Intensive Care Unit in the University Hospital of Brest (France) for non-traumatic SAH. Primary outcome is diagnosis of DCI on CT scan or MRI 3 months after SAH. Multivariate analysis is used to identify factors independently associated with DCI.

We plan to include between 200 and 250 patients in the analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-02-20
• Primary Completion: 2020-07-15
• Study Completion: 2020-07-15
• Status Verified: 2021-10
• Study First Submitted: 2021-10-14
• Study First Submitted QC: 2021-10-14
• Last Update Submitted: 2021-10-14
• Study First Posted: 2021-10-26
• Last Update Posted: 2021-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

• admitted in ICU in Brest University Hospital
• for non traumatic subarachnoid hemorrhage
• between july 2015 and december 2018

Exclusion Criteria

• continuation of care out of Brest University Hospital after initial ICU stay
• refusal to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
delayed cerebral infarction	3 months from subarachnoid hemorrhage	infarction on CT or MRI not related to initial bleeding

Trial Locations

Locations (1)

CHRU de Brest; 🇫🇷 Brest, France