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临床试验/NCT06300801
NCT06300801No Longer Available不适用

Postoperative Pancreatic Fistula in Patients Undergoing Pancreaticoduodenectomy

Erol Olcok Corum Training and Research Hospital0 个研究点开始时间: 2024年3月8日最近更新:
适应症

试验速览

阶段
不适用
状态
No Longer Available
发起方

研究概览

简要总结

Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality. Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following PD. In this study, the investigators aim to predict pancreatic fistula using the C-reactive protein-albumin ratio (CAR). The total number of participants expected to be included in this research comprises patients who underwent PD between 2017 and 2023 and developed pancreatic fistula. The participants invitation is based on the detection of a pancreatic fistula. This study is conducted for research purposes and participation is voluntary. No interventions will be performed on the participants as part of this study; however, we have prepared this form to obtain participant permission to gather certain information. If the participants consent to the use of information for scientific purposes with the guarantee of confidentiality, they will be asked to sign a consent form.

详细描述

Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality rates. Despite dramatic advancements in surgical techniques and perioperative management, reported morbidity and mortality rates following PD are 41.56% and 2.88%, respectively, which remain unsatisfactory. Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following PD. Therefore, accurate and timely prediction of POPF after PD is necessary to reduce secondary mortality from serious complications and optimize individual patient treatment decisions. The C-reactive protein-albumin ratio (CAR) is an inflammatory marker calculated by dividing serum CRP levels by albumin levels and has been associated with poor prognosis in sepsis patients. This study aimed to investigate the predictive significance of CAR for POPF.

研究设计

研究类型
Expanded Access

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged between 18 and 80 years
  • Diagnosed with pancreatic cancer
  • Patients without recurrence

排除标准

  • Patients who underwent total pancreatectomy
  • Data were not available
  • Patients outside the specified age range

研究者

发起方
Erol Olcok Corum Training and Research Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Bahadır Kartal

Principal Investigator

Erol Olcok Corum Training and Research Hospital

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