Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant
- Registration Number
- NCT05317416
- Lead Sponsor
- Pfizer
- Brief Summary
The purpose of this study is to evaluate whether elranatamab monotherapy can provide clinical benefit compared to lenalidomide monotherapy (control) in participants with newly diagnosed multiple myeloma after undergoing autologous stem cell transplant. In Part 1 and Part 2 of the study, participants in the study will either receive elranatamab (arm A and C) as an injection under the skin at the study clinic or lenalidomide orally once daily at home (arm B). Participation in the study will be approximately five years
- Detailed Description
Elranatamab is a bispecific antibody: binding of elranatamab to CD3-expressing T-cells and BCMA-expressing multiple myeloma cells causes targeted T-cell-mediated cytotoxicity.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 760
- Diagnosis of MM as defined according to IMWG criteria (Rajkumar, 2014) with measurable disease at diagnosis
- Part 1 patients must be MRD positive, Part 2 patients can be MRD negative or MRD positive
- History of induction therapy for newly diagnosed MM, followed by high dose therapy and autologous stem cell transplant. Randomization must occur within 120 days from the stem cell transplant. For participants who receive consolidation therapy after ASCT, randomization must occur within 60 days of consolidation and within 7 months from ASCT.
- Partial Response or better according to IMWG criteria at the time of randomization
- Must have an archival bone marrow aspirate sample(s) to identify the dominant malignant (index) clone by central laboratory NGS test (ClonoSEQ assay) that is used to track MRD status. This sample should preferably be collected before induction treatment (eg, at diagnosis) or before transplant.
- ECOG performance status ≤1
- Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤ 1
- Not pregnant and willing to use contraception
- Plasma cell leukemia
- Amyloidosis, Waldenström's macroglobulinemia
- POEMS syndrome
- Known active CNS involvement or clinical signs of myelomatous meningeal involvement
- Previous MM maintenance treatment
- Prior treatment with BCMA targeted therapy
- Any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ
- Active, uncontrolled bacterial, fungal, or viral infection, including (but not limited to) HBV, HCV, and known HIV or AIDS-related illness
- Previous administration with an investigational drug or vaccine within 30 days (or as determined by the local requirement) or 5 half-lives preceding the first dose of study intervention used in this study (whichever is longer)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A - Part 1 Elranatamab Elranatamab Arm B - Part 1 Lenalidomide Lenalidomide Arm B - Part 2 Lenalidomide Lenalidomide Arm C - Part 2 Elranatamab Elranatamab
- Primary Outcome Measures
Name Time Method Progression Free Survival Assessed for up to approximately 5 years Progression Free Survival assessed by Blinded Independent Central review per IMWG response criteria
- Secondary Outcome Measures
Name Time Method Overall Survival Assessed for up to approximately 5 years Defined as the time from randomization until death due to any cause
Minimal Residual Disease negativity rate 12 months after randomization Minimal Residual Disease negativity rate per IMWG criteria as assessed via Next Generation Sequencing
Sustained MRD negativity rate 24 months after randomization Sustained Minimal Residual Disease negativity rate per IMWG criteria as assessed via Next Generation Sequencing
Progression Free Survival Assessed for up to approximately 5 years Progression Free Survival by investigator per IMWG response criteria
Overall minimal residual disease negativity rate Assessed for up to approximately 5 years Minimal residual disease negativity rate per IMWG criteria
Duration of minimal residual disease negativity Assessed for up to approximately 5 years Minimal residual disease negativity per IMWG criteria
Sustained minimal residual disease negativity rate Assessed for up to approximately 5 years Minimal residual disease negativity per IMWG criteria that has lasted a minimum of 12 months
Complete response rate Assessed for up to approximately 5 years Complete response rate by blinded independent central review and by investigator per IMWG criteria
Duration of complete response Assessed for up to approximately 5 years Duration of complete response by blinded independent central review and by investigator per IMWG criteria
Frequency of adverse events Up to 90 days after last dose Adverse event as characterized by type, frequency, severity per the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5, seriousness and relationship to the study intervention
Frequency of laboratory abnormalities Assessed for up to approximately 5 years Pre-dose concentrations of elranatamab Assessed for up to approximately 5 years Pharmacokinetics of elranatamab (trough concentrations of elranatamab)
Post-dose concentrations of elranatamab Assessed for up to approximately 5 years Pharmacokinetics of elranatamab (Post-dose serum concentrations of elranatamab)"
Incidence and titers of Anti-Drug Antibody and Neutralizing Antibody against elranatamab Assessed for up to approximately 5 years Immunogenicity of elranatamab
Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Assessed for up to approximately 5 years Higher scores on the functional scales represent higher levels of functioning. Higher scores on the global health status/quality of life scale represent higher health status/quality of life. Higher scores on symptom scales/items represent a greater presence of symptoms
Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Myeloma 20 Assessed for up to approximately 5 years Higher scores on the functioning subscales (body image, future perspective) represent higher levels of functioning, whereas higher scores on the symptom subscales (disease symptoms, side effects) represent a greater presence of symptoms
Progression Free Survival 2 Assessed for up to approximately 5 years Progression Free Survival to the date of second objective disease progression by investigator per IMWG response criteria
Trial Locations
- Locations (219)
Hôpital Saint Antoine
🇫🇷Paris Cedex 12, France
Hopital Lyon Sud
🇫🇷Pierre Benite, France
Banner Gateway Medical Center
🇺🇸Gilbert, Arizona, United States
Banner MD Anderson Cancer Center
🇺🇸Gilbert, Arizona, United States
Ronald Reagan UCLA Medical Center
🇺🇸Los Angeles, California, United States
UCLA Hematology/Oncology - Westwood (Building 200 Suite 120)
🇺🇸Los Angeles, California, United States
UCLA Hematology/Oncology - Santa Monica
🇺🇸Los Angeles, California, United States
Shoalhaven District Memorial Hospital
🇦🇺Nowra, New South Wales, Australia
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
Miami Cancer Institute at Baptist Health, Inc.
🇺🇸Miami, Florida, United States
Emory University Hospital Midtown
🇺🇸Atlanta, Georgia, United States
Emory University Hospital
🇺🇸Atlanta, Georgia, United States
Investigational Drug Service, Emory University Clinic
🇺🇸Atlanta, Georgia, United States
Winship Cancer Institute, Emory University
🇺🇸Atlanta, Georgia, United States
Loyola University Chicago
🇺🇸Maywood, Illinois, United States
Ascentist Doctor Hospital
🇺🇸Leawood, Kansas, United States
American Oncology Partners, P.A. dba MidAmerica Cancer Care, LLC
🇺🇸Kansas City, Missouri, United States
O'Brien Pharmacy
🇺🇸Mission, Kansas, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
University Of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
WMCHealth Advanced Physician Services
🇺🇸Hawthorne, New York, United States
Westchester Medical Center
🇺🇸Valhalla, New York, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
OhioHealth Arthur G.H. Bing, MD, Cancer Center
🇺🇸Columbus, Ohio, United States
OhioHealth Research Institute
🇺🇸Columbus, Ohio, United States
OhioHealth Riverside Methodist Hospital
🇺🇸Columbus, Ohio, United States
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
Baylor Scott & White Medical Center - Temple
🇺🇸Temple, Texas, United States
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Wollongong Hospital
🇦🇺Wollongong, New South Wales, Australia
Pindara Private Hospital
🇦🇺Benowa, Queensland, Australia
QScan Radiology Clinics
🇦🇺Clayfield, Queensland, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Epworth Healthcare
🇦🇺East Melbourne, Victoria, Australia
Precision Haematology
🇦🇺East Melbourne, Victoria, Australia
St Vincent's Hospital (Melbourne)
🇦🇺Fitzroy, Victoria, Australia
Slade Pharmacy
🇦🇺Richmond, Australia
Medizinische Universität Wien
🇦🇹Wien, Austria
Hanusch-Krankenhaus
🇦🇹Vienna, Austria
Institut Jules Bordet
🇧🇪Anderlecht, Bruxelles-capitale, Région DE, Belgium
Grand Hôpital de Charleroi
🇧🇪Charleroi, Hainaut, Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi
🇧🇪Yvoir, Namur, Belgium
UZ Gent
🇧🇪Gent, Oost-vlaanderen, Belgium
ZNA Middelheim
🇧🇪Antwerpen, Belgium
Zna Cadix
🇧🇪Antwerpen, Belgium
UZ Brussel
🇧🇪Brussel, Belgium
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
🇧🇷Salvador, Bahia, Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Centro de Pesquisa Clínica - Área Administrativa
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital Amaral Carvalho
🇧🇷Jaú, SÃO Paulo, Brazil
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
🇧🇷Ribeirão Preto, SÃO Paulo, Brazil
BP - A Beneficencia Portuguesa de São Paulo
🇧🇷Sao Paulo, SÃO Paulo, Brazil
Clínica Médica São Germano LTDA
🇧🇷SP, SÃO Paulo, Brazil
Fundação Doutor Amaral Carvalho
🇧🇷Jaú, Brazil
Américas Medical City
🇧🇷Rio de Janeiro, Brazil
Instituto de Educação, Pesquisa e Gestão em Saúde
🇧🇷Rio de Janeiro, Brazil
ESHO Empresa de Serviços Hospitalares S.A/ Hospital Samaritano de Higienópolis
🇧🇷São Paulo, Brazil
HU UNIFESP / SPDM - Hospital São Paulo
🇧🇷São Paulo, Brazil
Universidade Federal de Sao Paulo
🇧🇷São Paulo, Brazil
Hospital Japonês Santa Cruz
🇧🇷São Paulo, Brazil
Clínica Médica São Germano S/S Ltda
🇧🇷São Paulo, Brazil
Arthur J.E. Child Comprehensive Cancer Centre
🇨🇦Calgary, Alberta, Canada
Dr. Everett Chalmers Regional Hospital
🇨🇦Fredericton, New Brunswick, Canada
Saint John Regional Hospital
🇨🇦Saint John, New Brunswick, Canada
Hamilton Health Sciences Corporation
🇨🇦Hamilton, Ontario, Canada
Princess Margaret Cancer Centre
🇨🇦Toronto, Ontario, Canada
Windsor Regional Hospital Cancer Program
🇨🇦Windsor, Ontario, Canada
Centre Integre Universitaire de la Santé et de Services Sociaux de l'Est-de-l'ile-de-Montreal,
🇨🇦Montreal, Quebec, Canada
McGill University Health Centre
🇨🇦Montreal, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎ
🇨🇦Montreal, Quebec, Canada
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Institute of hematology&blood disease hospital
🇨🇳Tianjin, Tianjin, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, Zhejiang, China
Fakultní nemocnice Brno Bohunice
🇨🇿Brno, Brno-město, Czechia
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Hradec Králové, Czechia
Fakultni nemocnice Ostrava
🇨🇿Ostrava, Moravskoslezský KRAJ, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
Vseobecna fakultni nemocnice v Praze
🇨🇿Praha 2, Czechia
Oulun yliopistollinen sairaala
🇫🇮Oulu, Pohjois-pohjanmaa, Finland
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
🇫🇮Helsinki, Uusimaa, Finland
Turku University Hospital
🇫🇮Turku, Varsinais-suomi, Finland
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE
🇫🇷Toulouse, Haute-garonne, France
Pitie Salpetriere University Hospital
🇫🇷Paris, Orne, France
Gustave Roussy
🇫🇷Villejuif, Val-de-marne, France
Centre Hospitalier Universitaire de Poitiers
🇫🇷Poitiers, Vienne, France
Chu Grenoble Alpes
🇫🇷La Tronche, France
Artemis hospital
🇮🇳Gurugram, Haryana, India
Hopital Claude Huriez - CHU de Lille
🇫🇷Lille, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
🇫🇷Tours, France
Universitätsklinikum Würzburg
🇩🇪Würzburg, Bayern, Germany
Universitätsmedizin Johannes Gutenberg Universität Mainz
🇩🇪Mainz, Rheinland-pfalz, Germany
Universitätsklinikum Leipzig
🇩🇪Leipzig, Sachsen, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
🇩🇪Kiel, Schleswig-holstein, Germany
Charite Universitätsmedizin Berlin Campus Benjamin Franklin
🇩🇪Berlin, Germany
Klinikum Chemnitz gGMbH
🇩🇪Chemnitz, Germany
Universitätsklinikum Essen
🇩🇪Essen, Germany
Klinikum rechts der Isar der Technischen Universität München
🇩🇪München, Germany
Alexandra General Hospital of Athens
🇬🇷Athens, Attikí, Greece
Theageneio Cancer Hospital of Thessaloniki
🇬🇷Thessaloniki, Kentrikí Makedonía, Greece
University Hospital of Ioannina
🇬🇷Ioannina, Ípeiros, Greece
Somogy Megyei Kaposi Mór Oktató Kórház
🇭🇺Kaposvár, Somogy, Hungary
Semmelweis University
🇭🇺Budapest, Hungary
Dél-Pesti Centrumkórház
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Jósa András Oktatókórház
🇭🇺Nyíregyháza, Hungary
Medanta-The Medicity
🇮🇳Gurugram, Haryana, India
Fortis Memorial Research Institute
🇮🇳Gurugram, Haryana, India
Himalayan Institute Hospital Trust University
🇮🇳Dehradun, Uttarakhand, India
Tata Medical Center
🇮🇳Kolkata, WEST Bengal, India
Rajiv Gandhi Cancer Institute And Research Centre
🇮🇳Delhi, India
Soroka Medical Center
🇮🇱Be'er Sheva, Hadarom, Israel
Rabin Medical Center
🇮🇱Petah-Tikva, Hamerkaz, Israel
Sheba Medical Center
🇮🇱Ramat Gan, Hamerkaz, Israel
Rambam Health Care Campus
🇮🇱Haifa, Hatsafon, Israel
Tel-Aviv Sourasky Medical Center Dana-Dwek Children's Hospital
🇮🇱Tel Aviv, Tell Abīb, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hadassah Medical Center
🇮🇱Jerusalem, Yerushalayim, Israel
Hadassah Mount Scopus Medical Center
🇮🇱Jerusalem, Yerushalayim, Israel
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
🇮🇹Meldola, Emilia-romagna, Italy
Fondazione Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Lazio, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Lombardia, Italy
Policlinico "G. Rodolico"
🇮🇹Catania, Sicilia, Italy
Azienda Ospedaliero Universitaria Senese
🇮🇹Siena, Toscana, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi
🇮🇹Ancona, Italy
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
🇮🇹Bologna, Italy
AOU Policlinico Umberto I
🇮🇹Roma, Italy
Nagoya City University Hospital
🇯🇵Nagoya, Aichi, Japan
Gunma University Hospital
🇯🇵Maebashi, Gunma, Japan
Kobe City Medical Center General Hospital
🇯🇵Kobe-city, Hyogo, Japan
Iwate Medical University Hospital
🇯🇵Yahaba-cho, Iwate, Japan
University Hospital,Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Tohoku University Hospital
🇯🇵Sendai, Miyagi, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Shizuoka Cancer Center
🇯🇵Sunto-gun, Shizuoka, Japan
Nippon Medical School Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
Kagoshima University Hospital
🇯🇵Kagoshima, Japan
National Hospital Organization Kumamoto Medical Center
🇯🇵Kumamoto, Japan
National Hospital Organization Okayama Medical Center
🇯🇵Okayama, Japan
Osaka Metropolitan University Hospital
🇯🇵Osaka, Japan
Japanese Red Cross Medical Center
🇯🇵Tokyo, Japan
Yamagata University Hospital
🇯🇵Yamagata, Japan
Gachon University Gil Medical Center
🇰🇷Namdong-gu, Incheon-gwangyeoksi [incheon], Korea, Republic of
Chonnam National University Hwasun Hospital
🇰🇷Hwasun Gun, Jeonranamdo, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Kyǒnggi-do, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Pusan-kwangyǒkshi, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital(Seoul St. Mary's Hospital)
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Kyungpook National University
🇰🇷Daegu, Taegu-kwangyǒkshi, Korea, Republic of
Kyungpook National University Hospital
🇰🇷Jung-gu, Taegu-kwangyǒkshi, Korea, Republic of
HagaZiekenhuis
🇳🇱Den Haag, Zuid-holland, Netherlands
Maastricht Universitair Medisch Centrum
🇳🇱Maastricht, Netherlands
Isala
🇳🇱Zwolle, Netherlands
Oslo Universitetssykehus Ullevål
🇳🇴Oslo, Norway
Stavanger Universitetssykehus
🇳🇴Stavanger, Norway
Centrum Medyczne Pratia Poznań
🇵🇱Skorzewo, Wielkopolskie, Poland
Uniwersyteckie Centrum Kliniczne,
🇵🇱Gdansk, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
🇵🇱Poznan, Poland
Uniwersyteckie Centrum Kliniczne WUM Centralny Szpital Kliniczny
🇵🇱Warszawa, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
🇵🇱Warszawa, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu
🇵🇱Wroclaw, Poland
Pratia Onkologia Katowice
🇵🇱Katowice, Śląskie, Poland
Complejo Hospitalario Universitario de Santiago
🇪🇸Santiago de Compostela, A Coruna, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Barcelona [barcelona], Spain
Institut Català d'Oncologia - L'Hospitalet
🇪🇸L'Hospitalet Del Llobregat, Barcelona [barcelona], Spain
Hospital Universitari Mutua Terrassa
🇪🇸Terrassa, Barcelona, Spain
Institut Catala d' Oncologia. Hospital Germans Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
Hospital Universitario de Salamanca
🇪🇸Salamanca, Castilla Y LEÓN, Spain
Hospital Clínic de Barcelona
🇪🇸Barcelona, Catalunya [cataluña], Spain
Clinica Universidad de Navarra
🇪🇸Madrid, Madrid, Comunidad DE, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Madrid, Comunidad DE, Spain
Hospital Universitario Quironsalud Madrid
🇪🇸Pozuelo de Alarcon, Madrid, Spain
Hospital San Pedro de Alcántara
🇪🇸Cáceres, Spain
Institut Catala Oncologia - Hospital Universitari de Girona Dr Josep Trueta
🇪🇸Gerona, Spain
Hospital La Princesa
🇪🇸Madrid, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario HM Sanchinarro
🇪🇸Madrid, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
🇪🇸Salamanca, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸València, Spain
Helsingborgs Lasarett
🇸🇪Helsingborg, Skåne LÄN [se-12], Sweden
Karolinska Universitetssjukhuset Huddinge
🇸🇪Stockholm, Stockholms LÄN [se-01], Sweden
Södra Älvsborgs Sjukhus Borås
🇸🇪Borås, Västra Götalands LÄN [se-14], Sweden
Falu Lasarett
🇸🇪Falun, Sweden
Universitetssjukhuset Örebro
🇸🇪Örebro, Örebro LÄN [se-18], Sweden
Universitetssjukhuset i Linköping
🇸🇪Linköping, Östergötlands LÄN [se-05], Sweden
CHUV (centre hospitalier universitaire vaudois)
🇨🇭Lausanne, Vaud, Switzerland
UniversitätsSpital Zürich
🇨🇭Zürich, Zürich (DE), Switzerland
Kantonsspital Baden
🇨🇭Baden, Switzerland
Inselspital Bern
🇨🇭Berne, Switzerland
Kantonsspital Winterthur
🇨🇭Winterthur, Switzerland
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch
🇨🇳Taoyuan, Taiwan
Medipol Mega Universite Hastanesi
🇹🇷İstanbul, İ̇stanbul, Turkey
Sisli Florence Nightingale Hastanesi
🇹🇷İstanbul, İ̇stanbul, Turkey
Ege Universitesi Hastanesi
🇹🇷Izmir, İ̇zmir, Turkey
Dokuz Eylul Universitesi Hastanesi
🇹🇷İzmir, İ̇zmir, Turkey
Ankara University Health Practice and Research Hospitals
🇹🇷Ankara, Turkey
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
🇹🇷Ankara, Turkey
Aydın Adnan Menderes Universitesi Hastanesi
🇹🇷Aydin, Turkey
Erciyes Universitesi Tıp Fakultesi Hastaneleri
🇹🇷Kayseri, Turkey
Özel Anadolu Sağlık Merkezi
🇹🇷Kocaeli, Turkey
Addenbrooke's Hospital
🇬🇧Cambridge, Cambridgeshire, United Kingdom
Queen Elizabeth Hospital Birmingham
🇬🇧Birmingham, England, United Kingdom
Dewsbury and District Hospital
🇬🇧Dewsbury, Wakefield, United Kingdom
Pontefract General Infirmary
🇬🇧Pontefract, Wakefield, United Kingdom
Belfast City Hospital
🇬🇧Belfast, United Kingdom
The Beatson West of Scotland Cancer Centre
🇬🇧Glasgow, United Kingdom
Royal Berkshire Hospital
🇬🇧Reading, United Kingdom
Pinderfields General Hospital
🇬🇧Wakefield, United Kingdom
New Cross Hospital
🇬🇧Wolverhampton, United Kingdom