NCT00120718已完成2 期
The Effect of Fasudil on Vascular Function in Humans
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Vascular reactivity
研究概览
简要总结
The purpose of the study is to evaluate how the rho kinase inhibitor, fasudil, affects vascular function in patients with atherosclerosis and hyperlipidemia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Coronary artery disease
- •Hyperlipidemia -OR-
- •Healthy adults
排除标准
- •Unstable angina, myocardial infarction or revascularization within 3 months
- •Symptomatic heart failure
- •Creatinine > 3.0 mg/dl
- •Liver enzymes > 3X upper limit of normal
- •Chronic hypoxia
- •Significant anemia
- •Chronic inflammatory disease
- •Pregnancy
- •Willing to withdraw statins for duration of study
结局指标
主要结局
Vascular reactivity
次要结局
- Rho kinase expression
- Rho kinase activity
- eNOS expression
- eNOS activity
- inflammatory markers
研究者
研究点 (1)
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