Taining Golden Lake Comprehensive Chronic Disease Management Initiative
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20,000
- 试验地点
- 1
- 主要终点
- Incidence of Major Adverse Cardiovascular Events (MACE)
研究概览
简要总结
This study aims to establish the first county-level, population-based prospective cohort in Taining County, Fujian Province, China. The cohort will include at least 20,000 residents aged 18 years or older. The project will systematically collect questionnaires, physical measurements, laboratory tests, imaging data, and biological samples to build a multi-dimensional health database and biobank. Through 3-year follow-up, the study seeks to reveal the epidemiological patterns and risk factors of chronic diseases, characterize the natural course of multimorbidity and aging syndromes, and develop a comprehensive chronic disease management model suitable for rural and mountainous regions.
详细描述
China is undergoing rapid population aging, with chronic non-communicable diseases (NCDs) becoming the leading cause of death and disability. Taining County, located in a mountainous area of Fujian Province, faces a higher-than-average aging population and a growing burden of hypertension, diabetes, dyslipidemia, and cardiovascular diseases. Early detection and standardized management remain insufficient, and healthcare resources are limited. This study will establish a prospective cohort covering ≥20,000 residents, integrating demographic, lifestyle, clinical, laboratory, and imaging data. Active follow-up will be conducted annually, complemented by passive follow-up through local healthcare and death registry systems. The study will (1) identify epidemiological features and risk factors of common chronic diseases, (2) explore multimorbidity and aging trajectories, and (3) develop a replicable "Taining Model" for chronic disease prevention and management at the county level. The results will provide an evidence base for public health decision-making and chronic disease control strategies in similar rural and mountainous regions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years, male or female.
- •Resident of Taining County for ≥6 months and expected to remain in the county for at least the next 3 years.
- •Full civil capacity and able to understand study procedures.
- •Willing to voluntarily participate and provide written informed consent.
- •Able to complete baseline survey and follow-up visits.
排除标准
- •Refusal to sign informed consent.
- •Severe psychiatric disorders or cognitive impairment preventing participation.
- •End-stage disease with expected survival <1 year.
- •Long-term migrants (≥6 months per year outside the county), unable to guarantee follow-up.
- •Participation in other clinical studies that may interfere with this research.
结局指标
主要结局
Incidence of Major Adverse Cardiovascular Events (MACE)
时间窗: Up to 36 months
Composite outcome including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Events will be ascertained through active follow-up and confirmed using medical records and hospital discharge summaries.
次要结局
- Bleeding Events(Up to 36 months)
- Health Economics Outcomes(Up to 36 months)
- Cognitive Function Outcomes(Baseline and annual follow-up (Year 1-3))
- Cancer Incidence and Cancer-Related Outcomes(Up to 36 months)
- All-Cause Mortality(Up to 36 months)
- Incidence of Cardiovascular and Cerebrovascular Events(Up to 36 months)
- Heart Failure-Related Rehospitalization Rate(Up to 36 months)
研究者
Dajun Chai
Professor and Chief Physician, Department of Cardiology
First Affiliated Hospital of Fujian Medical University